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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR LEUSTATIN

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Clinical Trials for Leustatin

Trial ID Title Status Sponsor Phase Summary
NCT00667329 Treatment of Macroglobulinemic Lymphoma With 2CdA, Cyclophosphamide and Rituximab Active, not recruiting M.D. Anderson Cancer Center N/A The goal of this clinical research study is to see how well the drugs 2CdA, cyclophosphamide, and rituximab (rituxan) shrink a lymphoma called Waldenstrom's macroglobulinemia. After these drugs are given for 2 courses, a second goal is to see how long a remission lasts. A third goal is to see how often repeat remissions can be achieved when the lymphoma returns later and the same drugs are restarted.
NCT01513603 Trial of Cladribine, Cytarabine, Mitoxantrone, Filgrastim (CLAG-M) in Relapsed Acute Lymphoblastic Leukemia Unknown status New York Medical College Phase 2 CLAG-M is an active, well tolerated regimen in acute myelogenous leukemia. Each of the agents is active in Acute Lymphoblastic Leukemia (ALL) as well. The current trial will determine the efficacy of the regimen in patients with relapsed ALL.
NCT03012672 Higher or Lower Dose Cladribine, Cytarabine, and Mitoxantrone in Treating Medically Less Fit Patients With Newly Diagnosed Acute Myeloid Leukemia or Myeloid Neoplasm Not yet recruiting National Cancer Institute (NCI) N/A This randomized pilot trial studies how well higher or lower dose cladribine, cytarabine, and mitoxantrone work in treating medically less fit patients with newly diagnosed acute myeloid leukemia or myeloid neoplasm. Drugs used in chemotherapy, such as cladribine, cytarabine, and mitoxantrone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving cladribine, cytarabine, and mitoxantrone at higher or lower dose may work better in treating patients with newly diagnosed acute myeloid leukemia.
NCT03012672 Higher or Lower Dose Cladribine, Cytarabine, and Mitoxantrone in Treating Medically Less Fit Patients With Newly Diagnosed Acute Myeloid Leukemia or Myeloid Neoplasm Not yet recruiting Fred Hutchinson Cancer Research Center N/A This randomized pilot trial studies how well higher or lower dose cladribine, cytarabine, and mitoxantrone work in treating medically less fit patients with newly diagnosed acute myeloid leukemia or myeloid neoplasm. Drugs used in chemotherapy, such as cladribine, cytarabine, and mitoxantrone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving cladribine, cytarabine, and mitoxantrone at higher or lower dose may work better in treating patients with newly diagnosed acute myeloid leukemia.
NCT03531918 Gemtuzumab Ozogamicin With G-CSF, Cladribine, Cytarabine and Mitoxantrone in Treating Participants With Previously Untreated Acute Myeloid Leukemia or High-Grade Myeloid Neoplasm Recruiting National Cancer Institute (NCI) Phase 1/Phase 2 This phase I/II trial studies the side effects and best dosing frequency of gemtuzumab ozogamicin when given in combination with granulocyte colony stimulating factor (G-CSF), cladribine, cytarabine and mitoxantrone (GCLAM) and to see how well they work in treating participants with acute myeloid leukemia or high-grade myeloid tumors (neoplasms) that have not been previously treated. Antibody-drug conjugates, such as gemtuzumab ozogamicin, act by directly delivering toxic chemotherapy to cancer cells. Granulocyte colony stimulating factor is a growth factor used to stimulate leukemia cells and render them more sensitive to chemotherapy drugs. Drugs used in chemotherapy, such as cladribine, cytarabine and mitoxantrone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving gemtuzumab ozogamicin in combination with G-CSF, cladribine, cytarabine and mitoxantrone hydrochloride may work better in treating participants with acute myeloid leukemia or high-grade myeloid neoplasm.
NCT03531918 Gemtuzumab Ozogamicin With G-CSF, Cladribine, Cytarabine and Mitoxantrone in Treating Participants With Previously Untreated Acute Myeloid Leukemia or High-Grade Myeloid Neoplasm Recruiting Fred Hutchinson Cancer Research Center Phase 1/Phase 2 This phase I/II trial studies the side effects and best dosing frequency of gemtuzumab ozogamicin when given in combination with granulocyte colony stimulating factor (G-CSF), cladribine, cytarabine and mitoxantrone (GCLAM) and to see how well they work in treating participants with acute myeloid leukemia or high-grade myeloid tumors (neoplasms) that have not been previously treated. Antibody-drug conjugates, such as gemtuzumab ozogamicin, act by directly delivering toxic chemotherapy to cancer cells. Granulocyte colony stimulating factor is a growth factor used to stimulate leukemia cells and render them more sensitive to chemotherapy drugs. Drugs used in chemotherapy, such as cladribine, cytarabine and mitoxantrone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving gemtuzumab ozogamicin in combination with G-CSF, cladribine, cytarabine and mitoxantrone hydrochloride may work better in treating participants with acute myeloid leukemia or high-grade myeloid neoplasm.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Leustatin

Condition Name

Condition Name for Leustatin
Intervention Trials
Acute Myeloid Leukemia 4
Blasts 10 Percent or Less of Bone Marrow Nucleated Cells 1
Lymphoma 1
Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive 1
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Condition MeSH

Condition MeSH for Leustatin
Intervention Trials
Leukemia, Myeloid 5
Leukemia 5
Leukemia, Myeloid, Acute 4
Neoplasms 3
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Clinical Trial Locations for Leustatin

Trials by Country

Trials by Country for Leustatin
Location Trials
United States 6
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Trials by US State

Trials by US State for Leustatin
Location Trials
Texas 3
Washington 2
New York 1
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Clinical Trial Progress for Leustatin

Clinical Trial Phase

Clinical Trial Phase for Leustatin
Clinical Trial Phase Trials
Phase 2 3
Phase 1/Phase 2 1
N/A 2
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Clinical Trial Status

Clinical Trial Status for Leustatin
Clinical Trial Phase Trials
Recruiting 2
Not yet recruiting 2
Unknown status 1
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Clinical Trial Sponsors for Leustatin

Sponsor Name

Sponsor Name for Leustatin
Sponsor Trials
National Cancer Institute (NCI) 4
M.D. Anderson Cancer Center 3
Fred Hutchinson Cancer Research Center 2
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Sponsor Type

Sponsor Type for Leustatin
Sponsor Trials
Other 6
NIH 4
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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Merck
Cantor Fitzgerald
Cipla
Express Scripts
Mallinckrodt
Argus Health
Farmers Insurance
US Department of Justice

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