Prophylactic Antibiotics for Prevention of Wound Complications Following Vulvectomy
Completed
Aultman Health Foundation
Phase 4
2007-10-01
This randomized prospective study will specifically investigate the efficacy of a 24 hour
post-operative course of broad-spectrum prophylactic antibiotics - namely Cefazolin - in
preventing wound infection and wound breakdown following vulvectomy.
Cefazolin Pharmacokinetics: Elimination Clearance in Neonates
Completed
Universitaire Ziekenhuizen Leuven
Phase 4
2011-02-01
To document cefazolin disposition (concentration/time profile, protein binding, metabolism,
renal elimination characteristics) and its covariates in neonates following intravenous
administration of the drug at induction of anesthesia, prior to an invasive procedure
To evaluate if optimalisation of cefazolin dose regimen during neonatal life is needed
Laparoscopy is a surgical procedure indicated for most gynecological pathologies and presents
numerous advantages over laparotomy, among them lower rates of surgical site infection and
less comorbidity feverish. Despite this, the use of antibiotic prophylaxis is widely accepted
and performed by most gynecologists. However, there isn't literature evidence to support the
routine use of antibiotics in the prophylaxis of wound infection on laparoscopic pelvic
surgery .Therefore, this study will evaluate the need for the use of antibiotic prophylaxis
in gynecological laparoscopies not including opening hollow viscera.
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