A clinical study to determine the safety and efficacy of sitagliptin in patients with Type 2
Diabetes Mellitus who have inadequate glycemic control on metformin/peroxisome
proliferator-activated receptor gamma (PPARg) agonist combination therapy.
People with high fasting glucose can develop type 2 diabetes with the passage of time. This
study is being done to determine the effect of a novel medication in people with this
elevated fasting glucose. Sitagliptin is a substance that raises levels of a hormone
normally found in the blood. This hormone, called glucagon-like peptide-1 (GLP-1), is
normally released by the intestine in response to the presence of food. This hormone acts
like a messenger between the intestine and the pancreas to raise insulin levels, and
therefore, lower blood sugars. Sitagliptin is effective in people with diabetes, however,
this study is being done to determine if Sitagliptin is effective in people with high
fasting glucose who do not yet have diabetes.
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