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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR IVABRADINE HYDROCHLORIDE

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Clinical Trials for Ivabradine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00143507 The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction Completed Institut de Recherches Internationales Servier Phase 3 The aim of this study is to test whether ivabradine is able to reduce cardiovascular events when given to patients with coronary artery disease and impaired heart function.
NCT00202566 Efficacy and Safety of Ivabradine on Top of Atenolol in Stable Angina Pectoris Completed Institut de Recherches Internationales Servier Phase 3 To test whether ivabradine when given in combination with atenolol is able to improve the exercise tolerance of patients with stable angina pectoris
NCT00202579 Efficacy and Safety of Ivabradine in Severe Congestive Heart Failure Completed Institut de Recherches Internationales Servier Phase 2 To evaluate the effects on heart function of ivabradine administered to patients with severe chronic heart failure
NCT00757055 If Channel Blockade With Ivabradine in Patients With Diastolic Heart Failure Withdrawn St Vincent's University Hospital, Ireland Phase 2 The purpose of this study is to investigate whether the medicine ivabradine, a novel drug which slows the heart rate has a favourable effect on patients with diastolic heart failure. Ivabradine is a specific heart rate-lowering agent. It has a licence for treating patients with angina who are intolerant of agents such as beta blockers or whose angina is not adequately controlled. It has been shown to prolong exercise tolerance in these patients and to reduce the frequency of chest pain. Its mechanism of action is felt to be purely due to reducing heart rate, by as much as 10 beats per minute at rest, as well as by reducing the heart rate response to exercise. Patients with diastolic heart failure often complain of breathlessness on exertion which relates to the stiffness or lack of compliance of their heart i.e. the heart fails to relax rapidly enough to allow it to fill with blood between each heart beat. This may result in high pressure in the heart chamber which backs up in to the lungs and may be experienced as breathlessness. There is little evidence that any specific therapy benefits patients with this type of heart failure besides treating coexisting problems such as high blood pressure or angina. By slowing the heart rate down with ivabradine, the heart would have a longer time to fill during exercise which would make it more effective. This slowing of the heart rate may therefore relieve the breathlessness experienced on activity such as walking to the shops or up a flight of stairs etc.
NCT00815100 Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome Unknown status Hospital Universitario de Canarias Phase 4 The purpose of this study is to investigate whether a pure heart rate-lowering agent (Ivabradine) reduces vascular inflammatory stress in patients with acute coronary syndromes
NCT00825123 Effects of Heart Rate Reduction on Central Arterial Pressure in Healthy Individuals Withdrawn Bayside Health Phase 4 The purpose of this project is to determine the effects of slowing heart rate upon both central and peripheral blood pressures using Ivabradine. The effects of Ivabradine will be compared to Metoprolol and placebo. Participants will attend the hospital for 3 visits where they will be randomised to receive either Ivabradine, Metoprolol and placebo on each visit. Non-invasive measures of blood pressure will be recorded before and after consuming the study drug.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Ivabradine Hydrochloride

Condition Name

Condition Name for Ivabradine Hydrochloride
Intervention Trials
Heart Failure 7
Coronary Artery Disease 5
Chronic Heart Failure 3
Angina Pectoris 2
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Condition MeSH

Condition MeSH for Ivabradine Hydrochloride
Intervention Trials
Heart Failure 22
Myocardial Ischemia 9
Coronary Disease 9
Coronary Artery Disease 9
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Clinical Trial Locations for Ivabradine Hydrochloride

Trials by Country

Trials by Country for Ivabradine Hydrochloride
Location Trials
United States 16
China 9
Italy 8
United Kingdom 5
Spain 3
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Trials by US State

Trials by US State for Ivabradine Hydrochloride
Location Trials
Michigan 3
New York 2
Delaware 1
California 1
Utah 1
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Clinical Trial Progress for Ivabradine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Ivabradine Hydrochloride
Clinical Trial Phase Trials
Phase 4 24
Phase 3 12
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Ivabradine Hydrochloride
Clinical Trial Phase Trials
Completed 19
Recruiting 9
Unknown status 9
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Clinical Trial Sponsors for Ivabradine Hydrochloride

Sponsor Name

Sponsor Name for Ivabradine Hydrochloride
Sponsor Trials
Amgen 5
Institut de Recherches Internationales Servier 4
Second University of Naples 3
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Sponsor Type

Sponsor Type for Ivabradine Hydrochloride
Sponsor Trials
Other 64
Industry 10
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