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Express Scripts
Fish and Richardson
UBS
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Fuji
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US Army
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Generated: December 12, 2018

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CLINICAL TRIALS PROFILE FOR ISOPROTERENOL HYDROCHLORIDE

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Clinical Trials for Isoproterenol Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00000568 Lung Health Study (LHS) I and III Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 In the Lung Health Study I, to determine the effects of Special Care, compared to Usual Care, on rate of decline in pulmonary function in a group of cigarette smokers identified as having mild abnormalities in pulmonary function. In the Lung Health Study III, to determine the long-term effects of smoking cessation and continued smoking, on cardiopulmonary morbidity, mortality, and the rate of decline in the one second forced expiratory volume (FEV1) in men and women with early chronic obstructive lung disease who have been followed prospectively for 12 to 15 years.
NCT00226551 Vascular Response to Isoproterenol and β2 Adrenergic Receptor Polymorphisms Completed Hadassah Medical Organization N/A Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic receptor (ß2AR) modify its pharmacological properties and may alter the response to ß2AR agonists. The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo. Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation. Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619. Using the organ bath technique, cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient.
NCT00323843 Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone Unknown status Fredericia Hosptial Phase 2 Is it possible to decrease the intrarenal pressure in the kidney during endoscopic management of kidney stone by topical administration of drugs? In order to secure fewer complications in ureteroscopic operations the pharmacological agent isoproterenol is tested on pigs and human to determine its potential of lowering intrarenal pressure.
NCT00428428 Pharmacological Modulation of the Intrarenal Pressure During Endourological Procedures in the Upper Urinary Tract Completed Fredericia Hosptial Phase 2/Phase 3 The purpose of the study is to examine the effect of endoluminally administrated isoproterenol on pelvic pressure increase during flexible ureterorenoscopy in 14 humans. We propose that isoproterenol has potential of reducing intrarenal pressure during ureterorenoscopies. Lower intrarenal pressures may have the advantage of facilitating the procedure and reducing intraoperative complications as bleeding and infections.
NCT00590538 Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis) Terminated Cystic Fibrosis Foundation Therapeutics Phase 1/Phase 2 The purpose of this research study is to test a new combination of medicines, Phenylbutyrate and Genistein, to determine if they could be used to treat cystic fibrosis (CF). The most common genetic mutation found in patients with CF is called Delta F508. Due to this mutation, there is a lack of salt (chloride) movement in your nose, sinuses, lungs, intestines, pancreas and sweat glands. This lack of movement causes the clinical manifestations of the disease. Although Phenylbutyrate has been extensively used to treat patients with rare metabolic diseases, Phenylbutyrate is an investigational drug for the purpose of this study. Genistein is a naturally occurring substance that is found in food products such as soy and tofu, but is also an investigational drug for this study. When used together, both drugs may be able to restore normal chloride and salt (water) movements in body organs and glands in people with CF. We will be studying salt and water movement in the nose by a technique called nasal transepithelial potential difference (NPD).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Isoproterenol Hydrochloride

Condition Name

Condition Name for Isoproterenol Hydrochloride
Intervention Trials
Atrial Fibrillation 3
Cystic Fibrosis 2
Kidney Stone 2
Postural Tachycardia Syndrome 2
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Condition MeSH

Condition MeSH for Isoproterenol Hydrochloride
Intervention Trials
Atrial Fibrillation 3
Syndrome 2
Nephrolithiasis 2
Postural Orthostatic Tachycardia Syndrome 2
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Clinical Trial Locations for Isoproterenol Hydrochloride

Trials by Country

Trials by Country for Isoproterenol Hydrochloride
Location Trials
United States 15
Denmark 2
Canada 1
Israel 1
Korea, Republic of 1
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Trials by US State

Trials by US State for Isoproterenol Hydrochloride
Location Trials
Oklahoma 3
Tennessee 2
Texas 2
Ohio 1
Florida 1
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Clinical Trial Progress for Isoproterenol Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Isoproterenol Hydrochloride
Clinical Trial Phase Trials
Phase 4 1
Phase 3 2
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Isoproterenol Hydrochloride
Clinical Trial Phase Trials
Completed 8
Recruiting 5
Not yet recruiting 3
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Clinical Trial Sponsors for Isoproterenol Hydrochloride

Sponsor Name

Sponsor Name for Isoproterenol Hydrochloride
Sponsor Trials
Vanderbilt University 3
Fredericia Hosptial 2
Laureate Institute for Brain Research, Inc. 2
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Sponsor Type

Sponsor Type for Isoproterenol Hydrochloride
Sponsor Trials
Other 33
NIH 1
Industry 1
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Covington
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