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Last Updated: May 27, 2022

CLINICAL TRIALS PROFILE FOR ISOFLURANE


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505(b)(2) Clinical Trials for Isoflurane

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
OTC NCT01691690 ↗ Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed Nationwide Children's Hospital Phase 2 2012-10-01 Acetaminophen (paracetamol) is a first-line antipyretic and analgesic for mild and moderate pain for pediatric patients. Its common use (particularly in oral form) is underscored by its wide therapeutic window, safety profile, over the counter accessibility, lack of adverse systemic effects (as compared with NSAIDS and opioids) when given in appropriate doses. Although the exact anti-nociceptive mechanisms of acetaminophen continue to be elucidated, these mechanisms appear to be multi-factorial and include central inhibition of the cyclo-oxygenase (COX) enzyme leading to decreased production of prostaglandins from arachidonic acid, interference with serotonergic descending pain pathways, indirect activation of cannabinoid 1 (CB1) receptors and inhibition of nitric oxide pathways through N-methyl-D-aspartate (NMDA) or substance P. Of the above mechanisms, the most commonly known is that of central inhibition of COX enzymes by which the decreased production of prostaglandins diminish the release of excitatory transmitters of substance P and glutamate which are both involved in nociceptive transmission (Anderson, 2008; Smith, 2011). To date, several studies have shown acetaminophen's opioid sparing effect in the pediatric population when given by the rectal or intravenous routes (Korpela et al, 1999; Dashti et al, 2009; Hong et al, 2010).
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Isoflurane

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000251 ↗ Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3 Completed National Institute on Drug Abuse (NIDA) Phase 2 1994-04-01 The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
NCT00000251 ↗ Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3 Completed University of Chicago Phase 2 1994-04-01 The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
NCT00000254 ↗ Isoflurane at Subanesthetic Concentrations - 6 Completed National Institute on Drug Abuse (NIDA) Phase 2 1995-01-01 The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
NCT00000254 ↗ Isoflurane at Subanesthetic Concentrations - 6 Completed University of Chicago Phase 2 1995-01-01 The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Isoflurane

Condition Name

Condition Name for Isoflurane
Intervention Trials
Anesthesia 14
Postoperative Pain 10
Pain, Postoperative 10
Dexmedetomidine 5
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Condition MeSH

Condition MeSH for Isoflurane
Intervention Trials
Pain, Postoperative 24
Hypotension 7
Heart Diseases 7
Delirium 6
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Clinical Trial Locations for Isoflurane

Trials by Country

Trials by Country for Isoflurane
Location Trials
Egypt 54
China 40
United States 33
Brazil 10
Canada 8
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Trials by US State

Trials by US State for Isoflurane
Location Trials
Ohio 4
Texas 4
North Carolina 4
New York 4
Illinois 3
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Clinical Trial Progress for Isoflurane

Clinical Trial Phase

Clinical Trial Phase for Isoflurane
Clinical Trial Phase Trials
Phase 4 72
Phase 3 18
Phase 2/Phase 3 7
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Clinical Trial Status

Clinical Trial Status for Isoflurane
Clinical Trial Phase Trials
Completed 111
Recruiting 37
Unknown status 28
[disabled in preview] 11
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Clinical Trial Sponsors for Isoflurane

Sponsor Name

Sponsor Name for Isoflurane
Sponsor Trials
Ain Shams University 9
Kasr El Aini Hospital 8
Fayoum University Hospital 8
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Sponsor Type

Sponsor Type for Isoflurane
Sponsor Trials
Other 282
Industry 6
NIH 5
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