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CLINICAL TRIALS PROFILE FOR ISOFLURANE

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Clinical Trials for Isoflurane

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00000251	Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3	Completed	National Institute on Drug Abuse (NIDA)	Phase 2	The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
NCT00000251	Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3	Completed	University of Chicago	Phase 2	The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
NCT00000254	Isoflurane at Subanesthetic Concentrations - 6	Completed	National Institute on Drug Abuse (NIDA)	Phase 2	The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
NCT00000254	Isoflurane at Subanesthetic Concentrations - 6	Completed	University of Chicago	Phase 2	The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
NCT00000259	Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11	Completed	National Institute on Drug Abuse (NIDA)	N/A	The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.

Clinical Trial Conditions for Isoflurane

Condition Name

Condition Name for Isoflurane
Intervention	Trials
Pain, Postoperative	7
Anesthesia	6
Postoperative Pain	4
Opioid-Related Disorders	3

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Condition MeSH

Condition MeSH for Isoflurane
Intervention	Trials
Pain, Postoperative	14
Delirium	5
Heart Diseases	5
Heart Valve Diseases	4

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Clinical Trial Locations for Isoflurane

Trials by Country

Trials by Country for Isoflurane
Location	Trials
United States	24
Egypt	18
China	11
Brazil	8
India	6

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Trials by US State

Trials by US State for Isoflurane
Location	Trials
New York	4
Ohio	3
Texas	3
North Carolina	3
Illinois	3

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Clinical Trial Progress for Isoflurane

Clinical Trial Phase

Clinical Trial Phase for Isoflurane
Clinical Trial Phase	Trials
Phase 4	51
Phase 3	11
Phase 2/Phase 3	5

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Clinical Trial Status

Clinical Trial Status for Isoflurane
Clinical Trial Phase	Trials
Completed	54
Recruiting	30
Not yet recruiting	20

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Clinical Trial Sponsors for Isoflurane

Sponsor Name

Sponsor Name for Isoflurane
Sponsor	Trials
Mansoura University	6
Assiut University	5
Postgraduate Institute of Medical Education and Research	5

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Sponsor Type

Sponsor Type for Isoflurane
Sponsor	Trials
Other	171
NIH	4
Industry	2

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