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Last Updated: November 12, 2019

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CLINICAL TRIALS PROFILE FOR ISOFLURANE

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505(b)(2) Clinical Trials for Isoflurane

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
OTC NCT01691690 Analgesic Effect of IV Acetaminophen in Tonsillectomies Active, not recruiting Nationwide Children's Hospital Phase 2 2012-10-01 Acetaminophen (paracetamol) is a first-line antipyretic and analgesic for mild and moderate pain for pediatric patients. Its common use (particularly in oral form) is underscored by its wide therapeutic window, safety profile, over the counter accessibility, lack of adverse systemic effects (as compared with NSAIDS and opioids) when given in appropriate doses. Although the exact anti-nociceptive mechanisms of acetaminophen continue to be elucidated, these mechanisms appear to be multi-factorial and include central inhibition of the cyclo-oxygenase (COX) enzyme leading to decreased production of prostaglandins from arachidonic acid, interference with serotonergic descending pain pathways, indirect activation of cannabinoid CB1 receptors and inhibition of nitric oxide pathways through N-methyl-D-aspartate (NMDA) or substance P. Of the above mechanisms, the most commonly known is that of central inhibition of COX enzymes by which the decreased production of prostaglandins diminish the release of excitatory transmitters of substance P and glutamate which are both involved in nociceptive transmission (Anderson, 2008; Smith, 2011). To date, several studies have shown acetaminophen's opioid sparing effect in the pediatric population when given by the rectal or intravenous routes (Korpela et al, 1999; Dashti et al, 2009; Hong et al, 2010).
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Isoflurane

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000251 Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3 Completed National Institute on Drug Abuse (NIDA) Phase 2 1994-04-01 The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
NCT00000251 Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3 Completed University of Chicago Phase 2 1994-04-01 The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
NCT00000254 Isoflurane at Subanesthetic Concentrations - 6 Completed National Institute on Drug Abuse (NIDA) Phase 2 1995-01-01 The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Isoflurane

Condition Name

Condition Name for Isoflurane
Intervention Trials
Pain, Postoperative 9
Postoperative Pain 6
Anesthesia 6
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Condition MeSH

Condition MeSH for Isoflurane
Intervention Trials
Pain, Postoperative 18
Heart Diseases 7
Delirium 5
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Clinical Trial Locations for Isoflurane

Trials by Country

Trials by Country for Isoflurane
Location Trials
United States 25
Egypt 22
China 11
Brazil 8
India 6
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Trials by US State

Trials by US State for Isoflurane
Location Trials
New York 4
Ohio 3
Texas 3
North Carolina 3
Illinois 3
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Clinical Trial Progress for Isoflurane

Clinical Trial Phase

Clinical Trial Phase for Isoflurane
Clinical Trial Phase Trials
Phase 4 54
Phase 3 12
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Isoflurane
Clinical Trial Phase Trials
Completed 56
Recruiting 33
Not yet recruiting 25
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Clinical Trial Sponsors for Isoflurane

Sponsor Name

Sponsor Name for Isoflurane
Sponsor Trials
Mansoura University 6
Assiut University 5
Postgraduate Institute of Medical Education and Research 5
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Sponsor Type

Sponsor Type for Isoflurane
Sponsor Trials
Other 188
NIH 4
Industry 2
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