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Last Updated: February 28, 2021

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CLINICAL TRIALS PROFILE FOR IRINOTECAN HYDROCHLORIDE

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505(b)(2) Clinical Trials for Irinotecan Hydrochloride

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Combination NCT00177853 Celecoxib, Irinotecan and Concurrent Radiotherapy in Preoperative Pancreatic Cancer Terminated Pharmacia and Upjohn Phase 1 2006-12-01 The purposes of this study are to examine the effects of a new combination of drugs, celecoxib (Celebrex®) and irinotecan (CPT-11), with standard radiation therapy on people before they undergo surgery; to determine what effects this combination has on pancreatic cancer; and to determine the highest dose of celecoxib and irinotecan that can be given safely without causing severe side effects. While not an endpoint, it is hoped that this combination will also shrink tumors enough for excision.
New Combination NCT00177853 Celecoxib, Irinotecan and Concurrent Radiotherapy in Preoperative Pancreatic Cancer Terminated University of Pittsburgh Phase 1 2006-12-01 The purposes of this study are to examine the effects of a new combination of drugs, celecoxib (Celebrex®) and irinotecan (CPT-11), with standard radiation therapy on people before they undergo surgery; to determine what effects this combination has on pancreatic cancer; and to determine the highest dose of celecoxib and irinotecan that can be given safely without causing severe side effects. While not an endpoint, it is hoped that this combination will also shrink tumors enough for excision.
New Combination NCT00215982 Study of Capecitabine With Irinotecan and Oxaliplatin (Eloxatin) in Advanced Colorectal Cancer Completed Roche Pharma AG Phase 2 2004-12-01 The purpose of this study is to find out how effective the new combination of the drugs Capecitabine (Xeloda), Oxaliplatin (Eloxatin), and Irinotecan (Camptosar) are against colon and rectal cancer. All three of these drugs are approved by the Food and Drug Administration (FDA) for the treatment of colon or rectal cancer. This however is the first time that these three drugs have been combined in this schedule for the treatment of colon/rectal cancer.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Irinotecan Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001495 A Phase I Study of Irinotecan (CPT-11) Administered as a Prolonged Infusion in Adult Patients With Solid Tumors Completed National Cancer Institute (NCI) Phase 1 1995-11-01 This study examines a 96 hour infusion schedule of irinotecan alternating with 72 hour drug-free intervals in patients with solid tumors in order to determine the maximum tolerated dose of this regimen.
NCT00002759 Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma Completed National Cancer Institute (NCI) Phase 1 1996-06-01 Phase I trial to study the effectiveness of irinotecan plus cyclosporine and phenobarbital in treating patients who have solid tumors or lymphoma that is refractory to standard therapy. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Cyclosporine and phenobarbital may enhance the effectiveness of irinotecan.
NCT00002902 Irinotecan Plus ICI D1694 in Treating Patients With Advanced Solid Tumors Completed National Cancer Institute (NCI) Phase 1 1997-04-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of irinotecan plus ICI D1694 in treating patients with advanced solid tumors.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Irinotecan Hydrochloride

Condition Name

Condition Name for Irinotecan Hydrochloride
Intervention Trials
Colorectal Cancer 240
Metastatic Colorectal Cancer 124
Gastric Cancer 62
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Condition MeSH

Condition MeSH for Irinotecan Hydrochloride
Intervention Trials
Colorectal Neoplasms 518
Adenocarcinoma 149
Pancreatic Neoplasms 127
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Clinical Trial Locations for Irinotecan Hydrochloride

Trials by Country

Trials by Country for Irinotecan Hydrochloride
Location Trials
United States 3,531
Canada 227
China 166
Japan 142
Italy 138
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Trials by US State

Trials by US State for Irinotecan Hydrochloride
Location Trials
California 195
New York 189
Texas 141
Illinois 132
Ohio 125
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Clinical Trial Progress for Irinotecan Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Irinotecan Hydrochloride
Clinical Trial Phase Trials
Phase 4 10
Phase 3 143
Phase 2/Phase 3 25
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Clinical Trial Status

Clinical Trial Status for Irinotecan Hydrochloride
Clinical Trial Phase Trials
Completed 518
Recruiting 277
Not yet recruiting 172
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Clinical Trial Sponsors for Irinotecan Hydrochloride

Sponsor Name

Sponsor Name for Irinotecan Hydrochloride
Sponsor Trials
National Cancer Institute (NCI) 278
Pfizer 47
Memorial Sloan Kettering Cancer Center 32
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Sponsor Type

Sponsor Type for Irinotecan Hydrochloride
Sponsor Trials
Other 1241
Industry 590
NIH 286
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