COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT
National University Hospital, Singapore
Phase 2/Phase 3
This is a randomised controlled trial to investigate the efficacy of preventive regimen of
hydration with high dose oral N-acetylcysteine and intravenous sodium bicarbonate
pretreatment in patients with stable advanced renal insufficiency (CKD stage 3 and 4:GFR
15-60ml/min/1.73m2 calculated by Modification of Diet in Renal Disease Study equation (MDRD
formula)) undergoing elective percutaneous coronary intervention (PCI).
Contrast-medium Induced Nephrotoxicity in Patients Undergoing Coronary Angiography - Iodixanol Versus Iopromide
Seoul National University Bundang Hospital
In the treatment of coronary heart disease which is the major cause of heart attack, direct
mechanical treatment with catheters such as the coronary angiography, coronary balloon
intervention and stenting intervention are the mainstay of therapy in recent years. In that
procedures, the investigators should use the contrast media, and it may cause kidney toxicity
especially in the patients with underlying kidney disease and decreased kidney function. The
investigators intended to find out which contrast agent has less kidney toxicity in the
catheter based treatment of coronary arterial diseases in patients with underlying decreased
Comparison Between Iso-Osmolar and Ipo-Osmolar Contrast Agents in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary Percutaneous Coronary Intervention (PCI)
Ospedale della Misericordia - Grosseto
The purpose of this study is to determine the incidence of contrast induced nephropathy and
myocardial tissue reperfusion following iso-osmolar iodixanol or ipo-osmolar iopromide
administration in patients with acute myocardial infarction undergoing primary PCI.
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