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Generated: December 17, 2018

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CLINICAL TRIALS PROFILE FOR IOHEXOL

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Clinical Trials for Iohexol

Trial ID Title Status Sponsor Phase Summary
NCT00028626 Portal Vein Embolization in Treating Patients With Liver Metastases From Primary Colorectal Cancer Completed National Cancer Institute (NCI) Phase 2 RATIONALE: Embolization blocks blood flow to part of an organ and/or tumor. Blocking the portal vein on one side of the liver may cause the opposite side of the liver to increase in size and decrease the risk of liver failure following surgery. PURPOSE: Phase II trial to study the effectiveness of portal vein embolization in treating patients who have liver metastases from primary colorectal cancer.
NCT00028626 Portal Vein Embolization in Treating Patients With Liver Metastases From Primary Colorectal Cancer Completed Memorial Sloan Kettering Cancer Center Phase 2 RATIONALE: Embolization blocks blood flow to part of an organ and/or tumor. Blocking the portal vein on one side of the liver may cause the opposite side of the liver to increase in size and decrease the risk of liver failure following surgery. PURPOSE: Phase II trial to study the effectiveness of portal vein embolization in treating patients who have liver metastases from primary colorectal cancer.
NCT00157586 Delapril and Manidipine for Nephroprotection in Diabetes (DEMAND) Completed Mario Negri Institute for Pharmacological Research Phase 3 Diabetes mellitus is one of the most common diseases globally, and is considered epidemic in many developed and newly industrialized nations. Diabetes mellitus represents the single largest cause of end-stage renal disease in the U.S. and Europe. At the same time, the primary cause of early death in diabetic patients are cardiovascular complications. Experimental and clinical studies found that angiotensin converting enzyme inhibitors (ACEi) and calcium channel blockers (CCBs) have a specific renoprotective effect and that this effect can be magnified when the two drugs are used in combination. To formally test this hypothesis we designed the Delapril and Manidipine for Nephroprotection in Diabetes (DEMAND) study, a prospective, randomized, double blind trial aimed to compare the effect of 3 years treatment with the ACEi Delapril (30 mg/day), alone or combined to the CCB Manidipine (10 mg/day), versus conventional (non ACEi, non CCB) therapy on the rate of renal function loss and on the incidence of major cardiovascular events in 342 normo- and micro-albuminuric hypertensive type 2 diabetic patients.
NCT00309283 Somatostatin in Polycystic Kidney: a Long-term Three Year Follow up Study Completed Mario Negri Institute for Pharmacological Research Phase 3 Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary renal disease, responsible for 8% to 10% of the cases of end stage renal disease (ESRD) in Western countries. At comparable levels of blood pressure control and proteinuria, patients with ADPKD have faster decline in glomerular filtration rate than those with other renal diseases and do not seem to benefit to the same extent of ACE inhibitor therapy. A reasonable explanation for the above findings is that in ADPKD progression is largely dependent on the development and growth of cysts and secondary disruption of normal tissue. Thus, renoprotective interventions in ADPKD - in addition to achieve maximal reduction of arterial blood pressure and proteinuria and to limit the effects of additional potential promoters of disease progression such as dyslipidemia, chronic hyperglycemia or smoking - should also be specifically aimed to correct the dysregulation of epithelial cell growth, secretion, and matrix interactions characteristic of the disease. Evidence that specific receptors for somatostatin are present in the kidney tissue, arises the possibility that somatostatin treatment in patients with ADPKD might inhibit fluid formation and eventually induce the shrinking of renal cysts.To evaluate the tolerability and the safety of long-acting somatostatin in ADPKD patients, a prospective cross-over controlled study has been recently performed. This pilot study demonstrated the safety of six month treatment of long-acting somatostatin in patients with ADPKD. Moreover, the percent increase of total kidney volume was significantly lower in patients on somatostatin than in placebo. Overall, these findings provide the basis for designing a long-term study in ADPKD patients aimed to document the efficacy of the somatostatin treatment in preventing further increase or even reducing the total kidney volume and the renal volume taken up by small cysts, eventually halting kidney disease progression.
NCT00478556 Omnipaque Versus Gastroview as Oral Contrast for Abdominal and Pelvic CT Completed GE Healthcare Phase 4 Patients who are scheduled by their health care provider for routine computed tomography (CT) scan will be asked to participate in this study. The primary purpose is to determine if there is a difference in patient preference for Omnipaque versus Gastroview as oral contrast for abdominal pelvic CT. A secondary objective is to evaluate if there is significant difference in bowel opacification for the two agents.
NCT00478556 Omnipaque Versus Gastroview as Oral Contrast for Abdominal and Pelvic CT Completed University of Alabama at Birmingham Phase 4 Patients who are scheduled by their health care provider for routine computed tomography (CT) scan will be asked to participate in this study. The primary purpose is to determine if there is a difference in patient preference for Omnipaque versus Gastroview as oral contrast for abdominal pelvic CT. A secondary objective is to evaluate if there is significant difference in bowel opacification for the two agents.
NCT00497328 COmbined N-acetylcysteine and Bicarbonate in PCI To Reduce Adverse Side Effect of contrasT Completed National University Hospital, Singapore Phase 2/Phase 3 This is a randomised controlled trial to investigate the efficacy of preventive regimen of hydration with high dose oral N-acetylcysteine and intravenous sodium bicarbonate pretreatment in patients with stable advanced renal insufficiency (CKD stage 3 and 4:GFR 15-60ml/min/1.73m2 calculated by Modification of Diet in Renal Disease Study equation (MDRD formula)) undergoing elective percutaneous coronary intervention (PCI).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Iohexol

Condition Name

Condition Name for Iohexol
Intervention Trials
Healthy 4
Acute Kidney Injury 4
HIV 2
Chronic Kidney Disease 2
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Condition MeSH

Condition MeSH for Iohexol
Intervention Trials
Kidney Diseases 6
Acute Kidney Injury 5
Renal Insufficiency 5
Diabetes Mellitus, Type 2 2
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Clinical Trial Locations for Iohexol

Trials by Country

Trials by Country for Iohexol
Location Trials
United States 33
France 7
Italy 5
Canada 5
Korea, Republic of 3
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Trials by US State

Trials by US State for Iohexol
Location Trials
California 6
Georgia 2
New York 2
Florida 2
Washington 2
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Clinical Trial Progress for Iohexol

Clinical Trial Phase

Clinical Trial Phase for Iohexol
Clinical Trial Phase Trials
Phase 4 9
Phase 3 8
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Iohexol
Clinical Trial Phase Trials
Completed 22
Recruiting 6
Not yet recruiting 5
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Clinical Trial Sponsors for Iohexol

Sponsor Name

Sponsor Name for Iohexol
Sponsor Trials
GE Healthcare 3
Mario Negri Institute for Pharmacological Research 3
MediBeacon 3
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Sponsor Type

Sponsor Type for Iohexol
Sponsor Trials
Other 45
Industry 23
NIH 4
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Serving hundreds of leading biopharmaceutical companies globally:

Farmers Insurance
Dow
Merck
Baxter
Fish and Richardson
Cantor Fitzgerald
Fuji
Johnson and Johnson
AstraZeneca

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