Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects
The purpose of this study is to assess the effect of LX4211 and the comparator drug
canagliflozin on intestinal glucose absorption and metabolism after a single dose in healthy
subjects in comparison to placebo.
Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM)
Active, not recruiting
Janssen Research & Development, LLC
The purpose of this study is to assess changes from baseline in insulin sensitivity, hepatic
fat content and beta cell function after approximately 24-25 weeks of treatment with
canagliflozin compared to placebo in participants with type 2 diabetes mellitus (T2DM) with
inadequate glycemic (blood sugar) control on metformin monotherapy or on combination therapy
with metformin and a dipeptidyl peptidase-4 (DPP-4) inhibitor.
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