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Generated: December 18, 2018

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CLINICAL TRIALS PROFILE FOR INVOKANA

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Clinical Trials for Invokana

Trial ID Title Status Sponsor Phase Summary
NCT01877889 A Study to Compare the Pharmacodynamics of Canagliflozin and Dapagliflozin in Healthy Volunteers Completed Janssen-Cilag International NV Phase 1 The purpose of this study is to compare the pharmacodynamics (ie, how the drug affects the body) of canagliflozin with the pharmacodynamics of dapagliflozin.
NCT01916863 Study to Evaluate the Effect of Single Doses of LX4211 and Canagliflozin on Intestinal Glucose Absorption in Healthy Adult Subjects Completed Lexicon Pharmaceuticals Phase 1 The purpose of this study is to assess the effect of LX4211 and the comparator drug canagliflozin on intestinal glucose absorption and metabolism after a single dose in healthy subjects in comparison to placebo.
NCT02009488 Treatment Differences Between Canagliflozin and Placebo in Insulin Secretion in Subjects With Type 2 Diabetes Mellitus (T2DM) Active, not recruiting Janssen Research & Development, LLC Phase 1 The purpose of this study is to assess changes from baseline in insulin sensitivity, hepatic fat content and beta cell function after approximately 24-25 weeks of treatment with canagliflozin compared to placebo in participants with type 2 diabetes mellitus (T2DM) with inadequate glycemic (blood sugar) control on metformin monotherapy or on combination therapy with metformin and a dipeptidyl peptidase-4 (DPP-4) inhibitor.
NCT02243202 Effects of Co-administration of Canagliflozin 300 mg and Phentermine 15 mg With Placebo in the Treatment of Non-Diabetic Overweight and Obese Participants Completed Janssen Research & Development, LLC Phase 2 The purpose of this study is to compare the effects of canagliflozin and phentermine to those of placebo to promote on a change in body weight over a 26 week period.
NCT02324842 Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients Recruiting Janssen Scientific Affairs, LLC N/A Specific Aim 1.To examine whether the combination of liraglutide plus canagliflozin can prevent the increase in HGP following institution of canagliflozin therapy and produce an additive or even synergistic effect to lower the plasma glucose concentration and A1c. Specific Aim 2: To examine whether combination therapy with liraglutide plus canagliflozin can produce an additive, or even synergistic, effect to promote weight loss and reduction in hepatic and visceral fat content. Specific Aim 3. To examine whether combination therapy with liraglutide plus canagliflozin can produce an additive or even synergistic effect to reduce systolic/diastolic blood pressure and 24-hour integrated blood pressure.
NCT02324842 Effect of Combined Incretin-Based Therapy Plus Canagliflozin on Glycemic Control and the Compensatory Rise in Hepatic Glucose Production in Type 2 Diabetic Patients Recruiting Ralph DeFronzo N/A Specific Aim 1.To examine whether the combination of liraglutide plus canagliflozin can prevent the increase in HGP following institution of canagliflozin therapy and produce an additive or even synergistic effect to lower the plasma glucose concentration and A1c. Specific Aim 2: To examine whether combination therapy with liraglutide plus canagliflozin can produce an additive, or even synergistic, effect to promote weight loss and reduction in hepatic and visceral fat content. Specific Aim 3. To examine whether combination therapy with liraglutide plus canagliflozin can produce an additive or even synergistic effect to reduce systolic/diastolic blood pressure and 24-hour integrated blood pressure.
NCT02360774 Mechanisms of Weight Loss With SGLT2 Inhibition Recruiting Janssen Scientific Affairs, LLC Phase 4 The purpose of this study is to investigate the effect of canagliflozin, a medication approved by the FDA for the treatment of type 2 diabetes, on body weight and metabolism in people with type 2 diabetes who are overweight or obese. Canagliflozin lowers glucose levels in the blood by making the kidneys excrete, rather than absorb, glucose. Canagliflozin is also often associated with weight loss. The study population will generally be type 2 diabetics, ages 18-75 years old, who are overweight or obese.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Invokana

Condition Name

Condition Name for Invokana
Intervention Trials
Diabetes Mellitus, Type 2 5
Obesity 3
Type 2 Diabetes Mellitus 2
Type 2 Diabetes 2
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Condition MeSH

Condition MeSH for Invokana
Intervention Trials
Diabetes Mellitus 11
Diabetes Mellitus, Type 2 10
Overweight 2
Heart Failure 2
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Clinical Trial Locations for Invokana

Trials by Country

Trials by Country for Invokana
Location Trials
United States 28
United Kingdom 3
Germany 1
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Trials by US State

Trials by US State for Invokana
Location Trials
Texas 3
California 3
Massachusetts 3
Virginia 2
Florida 2
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Clinical Trial Progress for Invokana

Clinical Trial Phase

Clinical Trial Phase for Invokana
Clinical Trial Phase Trials
Phase 4 10
Phase 2 1
Phase 1 4
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Clinical Trial Status

Clinical Trial Status for Invokana
Clinical Trial Phase Trials
Recruiting 8
Not yet recruiting 4
Completed 3
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Clinical Trial Sponsors for Invokana

Sponsor Name

Sponsor Name for Invokana
Sponsor Trials
Janssen Scientific Affairs, LLC 7
Janssen Research & Development, LLC 2
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2
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Sponsor Type

Sponsor Type for Invokana
Sponsor Trials
Other 21
Industry 12
NIH 2
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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Covington
Deloitte
Merck
Mallinckrodt
Cerilliant
Farmers Insurance
Fuji
AstraZeneca

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