This trial is designed to study the effects of various mechanistically unique medications in
controlling excessive increases in heart rate with standing and in improving the symptoms of
orthostatic intolerance in patients with this disorder.
This trial is designed to study the effects of various mechanistically unique medications in
controlling excessive increases in heart rate with standing and in improving the symptoms of
orthostatic intolerance in patients with this disorder.
Nicotinic Receptor Augmentation of SSRI Antidepressants
Completed
Donaghue Medical Research Foundation
Phase 2
2003-01-01
The purpose of this study is to determine whether the nicotinic receptor antagonist
mecamylamine hydrochloride (Inversine) can augment SSRI-refractory major depression symptoms,
quality of life and cigarette smoking outcomes. A total of n=60 SSRI-refractory patients who
are on stable doses of an SSRI are being recruited into this 8-week double-blind, randomized,
placebo-controlled trial.
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