Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes
Novo Nordisk A/S
This trial is conducted globally. The aim of this trial is to compare the efficacy and
safety of insulin degludec/liraglutide (IDegLira) versus insulin degludec (IDeg) and
liraglutide (Lira) in subjects with type 2 diabetes. Subjects are to continue their
pre-trial treatment with metformin or metformin + pioglitazone throughout the entire trial.
Comparison of the Efficacy and Safety of Two Intensification Strategies in Subjects With Type 2 Diabetes Inadequately Controlled on Basal Insulin and Metformin
Novo Nordisk A/S
This trial is conducted in Europe and North America. The aim of this trial is to compare the
efficacy and safety of adding liraglutide versus addition of insulin aspart with the largest
meal to insulin degludec in subjects with type 2 diabetes.
Eligible subjects with an HbA1c equal to or above 7% at end of treatment in NN1250-3643
(NCT01193309) trial will be randomised to receive treatment intensification while subjects
with an HbA1c below 7% at end of treatment in NN1250-3643 (NCT01193309) may continue to
receive insulin degludec treatment. Subjects are to continue their pre-trial metformin
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