Safety Study of AP24534 to Treat Chronic Myelogenous Leukemia (CML) and Other Hematological Malignancies
Active, not recruiting
The purpose of this study is to determine the maximum tolerated dose or a recommended dose
of oral AP24534 in a defined schedule (QD) in patients with refractory or advanced chronic
myelogenous leukemia and other refractory hematologic malignancies.
Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL)
Active, not recruiting
The purpose of this study is to determine the efficacy of ponatinib in patients with chronic
myeloid leukemia (CML) in chronic phase (CP), accelerated phase (AP) or blast phase (BP) or
with Ph positive (Ph+) acute lymphoblastic leukemia (ALL) who either are resistant or
intolerant to either dasatinib or nilotinib, or have the T315I mutation.
Targeted Therapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia
National Cancer Institute (NCI)
This phase II trial studies how well targeted therapy works in treating patients with acute
lymphoblastic leukemia or acute myelogenous leukemia that has come back after a period of
improvement or does not respond to treatment. Testing patients' blood or bone marrow to find
out if their type of cancer may be sensitive to a specific drug may help doctors choose more
effective treatments. Dasatinib, nilotinib, sunitinib malate, sorafenib tosylate, and
ponatinib hydrochloride may stop the growth of cancer cells by blocking some of the enzymes
needed for cell growth. Giving targeted therapy based on cancer type may be an effective
treatment for acute lymphoblastic leukemia or acute myelogenous leukemia.
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