Safety Study of AP24534 to Treat Chronic Myelogenous Leukemia (CML) and Other Hematological Malignancies
The purpose of this study is to determine the maximum tolerated dose or a recommended dose of
oral AP24534 in a defined schedule in patients with refractory or advanced chronic
myelogenous leukemia and other refractory hematologic malignancies.
Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL)
The purpose of this study is to determine the efficacy of ponatinib in patients with chronic
myeloid leukemia (CML) in chronic phase (CP), accelerated phase (AP) or blast phase (BP) or
with philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who either are
resistant or intolerant to either dasatinib or nilotinib, or have the
(T)hreonine-315-(I)soleucine (T315I) mutation.
Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia
This phase II trial studies the side effects and how well combination chemotherapy and
ponatinib hydrochloride work in treating patients with acute lymphoblastic leukemia. Drugs
used in chemotherapy, such as cyclophosphamide, vincristine sulfate, doxorubicin
hydrochloride, and dexamethasone, work in different ways to stop the growth of cancer cells,
either by killing the cells, by stopping them from dividing, or by stopping them from
spreading. Ponatinib hydrochloride may stop the growth of cancer cells by blocking some of
the enzymes needed for cell growth. Giving combination chemotherapy and ponatinib
hydrochloride may be an effective treatment for acute lymphoblastic leukemia.
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