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Generated: November 15, 2018

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CLINICAL TRIALS PROFILE FOR IBUPROFEN

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Clinical Trials for Ibuprofen

Trial ID Title Status Sponsor Phase Summary
NCT00000574 Ibuprofen in Sepsis Study Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 To determine the effects of ibuprofen on mortality, development and reversal of shock, and adult respiratory distress syndrome, and on Lung Parenchymal Injury Score in adult patients with serious infection.
NCT00000574 Ibuprofen in Sepsis Study Completed Vanderbilt University Medical Center Phase 3 To determine the effects of ibuprofen on mortality, development and reversal of shock, and adult respiratory distress syndrome, and on Lung Parenchymal Injury Score in adult patients with serious infection.
NCT00000728 Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 To evaluate the short-term effects of administering zidovudine ( AZT ) at the same time with increasing doses of aldesleukin ( interleukin-2; IL-2 ) in patients with persistent generalized lymphadenopathy syndrome ( PGL ). The effects to be studied include safety or toxicity, how quickly the drugs are used in the body, effects on the immune system, effects on HIV, concentrations in body fluids, and how quickly the drugs are cleared by the kidneys. The trial will establish the maximum tolerated dose ( MTD ) and will be a pilot study to determine the dose that has the greatest effect in the immune system. AZT has been shown to be effective in HIV-related disease. IL-2 has been shown to increase immune responses and correct immune problems caused by HIV in the test tube. IL-2 has also been effective in treating Kaposi's sarcoma in a number of patients. Because of the clinical activities of these two drugs and because their toxicities and mechanisms of action do not overlap, it may be beneficial to combine the two drugs with their antiviral and immune stimulatory effects.
NCT00001005 A Study of Zidovudine Plus Interleukin-2 in HIV-Infected Patients Who Have No Symptoms of Infection But Who Have Tender Lymph Nodes Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 AMENDED: To investigate whether subcutaneous (SC) injection of IL-2 produces biological responses which parallel those observed with IV dosing. Original design: To evaluate the short-term effects of combined administration of zidovudine (AZT) and increasing doses of recombinant interleukin-2 (aldesleukin; IL-2) in patients infected with HIV, who have lymphadenopathy, but who are otherwise asymptomatic (no other symptoms). The first phase of this clinical trial will establish maximum tolerated dose ( MTD ). How quickly the drugs get into the blood and how long they remain there (pharmacokinetics) will also be studied at each dose as well as the effect on HIV. Since AZT has no effect on cells that contain inactive virus (latently infected cells) and these cells may act as viral reservoirs, that a second agent that can destroy these infected cells would be useful in combination with AZT. The different activities of AZT and IL-2, as well as the non-overlapping nature of their mechanisms of action and toxicity, increase the theoretical benefits of combining AZT, a drug which has clinically significant activity in HIV-related disease but cannot eliminate infected cells, with IL-2, a drug which may enhance anti-HIV immunity, destroy chronically infected cells, and allow immune recognition of latently infected cells.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Ibuprofen

Condition Name

Condition Name for Ibuprofen
Intervention Trials
Pain 83
Healthy 29
Patent Ductus Arteriosus 22
Pain, Postoperative 22
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Condition MeSH

Condition MeSH for Ibuprofen
Intervention Trials
Pain, Postoperative 57
Osteoarthritis 35
Ductus Arteriosus, Patent 31
Toothache 27
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Clinical Trial Locations for Ibuprofen

Trials by Country

Trials by Country for Ibuprofen
Location Trials
United States 714
United Kingdom 41
Canada 41
Brazil 26
Germany 26
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Trials by US State

Trials by US State for Ibuprofen
Location Trials
Texas 52
California 51
Pennsylvania 41
New York 39
Utah 32
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Clinical Trial Progress for Ibuprofen

Clinical Trial Phase

Clinical Trial Phase for Ibuprofen
Clinical Trial Phase Trials
Phase 4 160
Phase 3 111
Phase 2/Phase 3 18
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Clinical Trial Status

Clinical Trial Status for Ibuprofen
Clinical Trial Phase Trials
Completed 298
Recruiting 88
Not yet recruiting 65
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Clinical Trial Sponsors for Ibuprofen

Sponsor Name

Sponsor Name for Ibuprofen
Sponsor Trials
Pfizer 41
Merck Sharp & Dohme Corp. 18
Cumberland Pharmaceuticals 17
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Sponsor Type

Sponsor Type for Ibuprofen
Sponsor Trials
Other 510
Industry 250
NIH 25
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Serving hundreds of leading biopharmaceutical companies globally:

Citi
Cerilliant
McKesson
Colorcon
Mallinckrodt
Federal Trade Commission
Chubb
Covington
Boehringer Ingelheim

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