Hypertension is one of the most common medical problems in the United States and in the VA
health care system. It has been well-documented that hypertension can be effectively
treated. However, there remain important unresolved clinical questions in the area of
antihypertensive treatment. For example, how much is mortality affected by visit compliance,
blood pressure control and type of antihypertensive agent? Or, are some regimens associated
with more morbidity than others? Or, are there inexpensive regimens that are as effective as
more expensive regimens? The amount of data that is available from this demonstration
project (currently 6,100 patients) will help address these questions. The answers to these
questions should result in better care for veterans with hypertension.
PHARES Study: Management of Resistant Hypertension
Assistance Publique - Hôpitaux de Paris
The purpose of this study is to assess the efficacy of two different treatment regimens for
treating resistant hypertension previously uncontrolled with at least 3 antihypertensive
treatments. The study hypothesis is that these two regimens (one based on increasing
diuretics and the other based on increasing renin angiotensin system blockage) may not
differ in terms of efficacy.
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