Paclitaxel, Cisplatin, and Topotecan With or Without Filgrastim in Treating Patients With Newly Diagnosed Stage III or Stage IV Epithelial Ovarian Cancer
Completed
National Cancer Institute (NCI)
Phase 1
1996-12-01
Phase I trial to study the effectiveness of paclitaxel, cisplatin, and topotecan with or
without filgrastim in treating patients who have newly diagnosed stage III or stage IV
epithelial ovarian cancer. Drugs used in chemotherapy use different ways to stop tumor cells
from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim may
increase the number of immune cells found in bone marrow or peripheral blood and may help a
person's immune system recover from the side effects of chemotherapy
Amifostine Plus Topotecan in Treating Patients With Myelodysplastic Syndrome
Completed
University of Arizona
Phase 1/Phase 2
1998-09-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Chemoprotective drugs such as amifostine may protect normal cells
from the side effects of chemotherapy.
PURPOSE: Phase I/II trial to study the effectiveness of amifostine plus topotecan in treating
patients with myelodysplastic syndrome.
Sequential Chemotherapy in Treating Patients With Residual Disease Following Surgery for Stage IIB, Stage III, or Stage IV Ovarian Cancer
Unknown status
SmithKline Beecham
Phase 2
1997-12-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Giving chemotherapy drugs in different ways may kill more tumor
cells.
PURPOSE: Phase II trial to study the effectiveness of sequential chemotherapy in treating
patients with residual disease following surgery for stage IIB, stage III, or stage IV
ovarian cancer.
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