Use of Impedance Cardiography and Applanation Tonometry for Prediction of the Antihypertensive Effect of Two Drugs
Completed
AHEPA University Hospital
N/A
2014-11-10
The principal aim of the study is to determine whether the hemodynamic parameters measured
with the two methods -impedance cardiography and applanation tonometry- can be predictive of
the antihypertensive effect of two different classes of drugs, ATII antagonists and
diuretics.
The drugs that will be used in the study are olmesartan and chlorthalidone and the duration
of the study is 12 months.
The other basic aim of the study is to determine whether there is a difference (>6mmHg)
between the two drugs regarding the reduction of the mean 24hour blood pressure and the
effect of them on the hemodynamic parameters.
The hemodynamic parameters that will be measured by applanation tonometry are augmentation
index, central blood pressure and pulse wave velocity.
The hemodynamic parameters that will be measured by impedance cardiography are cardiac index,
thoracic fluid content index, systemic vascular resistance index and others.
Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in Obesity
Recruiting
Brigham and Women's Hospital
Phase 4
2020-12-01
This study will evaluate whether the mineralocorticoid receptor antagonist eplerenone, when
compared to chlorthalidone plus potassium chloride, can improve cardiac MRI-derived
myocardial perfusion reserve and fibrosis, independent of blood pressure, and proportionately
to the severity of autonomous aldosterone production.
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