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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR GONADOTROPIN, CHORIONIC


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505(b)(2) Clinical Trials for Gonadotropin, Chorionic

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
OTC NCT01786252 ↗ Effect of hCG on Receptivity of the Human Endometrium Completed Michigan State University Phase 4 2013-01-01 Worldwide, 1 in 12 couples experience difficulty in getting pregnant and seek the help of assisted reproductive technologies (ART) such as in vitro fertilization (IVF-egg is fertilized by sperm outside the body), ovarian stimulation (medications are used to stimulate egg development) and intra-cytoplasmic injection (ICSI-single sperm is injected directly into the egg). Regardless of the ART procedure being performed, the newly fertilized embryo must still implant into the mothers endometrium (inner lining of uterus). This implantation process in humans is surprisingly inefficient and accounts for up to 50% of ART failures. Intrauterine infusion of hCG prior to embryo transfer has recently been shown to increase pregnancy rates but the cellular mechanism for this increase is unknown. Successful implantation requires the newly fertilized embryo and the endometrium develop in a synchronized manner. This coordinated development is accomplished, in part, by proteins secreted by the embryo which circulate throughout the maternal bloodstream and alert the maternal body organs (i.e. ovary, endometrium, breast, ect) that fertilization has occurred. One of the earliest of these secreted proteins is human chorionic gonadotropin (hCG), which is the molecule detected in over-the-counter pregnancy tests. From previous studies, we know that hCG production by the embryo alerts the ovary to continue producing progesterone, a hormone required for pregnancy. However, very little is known about the direct effect of hCG on the endometrium during early pregnancy in humans. Using animal models, hCG has been shown to induce specific changes in the endometrium, suggesting that embryo-derived hCG may be "priming" the endometrium in anticipation of implantation. The goal of this research study is to examine the direct effect of hCG on the human endometrium and see if this "priming effect" is also present in humans. Findings from this research may reveal whether pre-treatment with hCG can enhance ART outcomes, especially pregnancy rates.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Gonadotropin, Chorionic

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00002596 ↗ Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed Cancer and Leukemia Group B Phase 3 1994-09-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not known whether combining chemotherapy with bone marrow or peripheral stem cell transplantation is more effective than combination chemotherapy alone in treating men with germ cell tumors. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without bone marrow or peripheral stem cell transplantation in treating men with previously untreated germ cell tumors.
NCT00002596 ↗ Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed Eastern Cooperative Oncology Group Phase 3 1994-09-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not known whether combining chemotherapy with bone marrow or peripheral stem cell transplantation is more effective than combination chemotherapy alone in treating men with germ cell tumors. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without bone marrow or peripheral stem cell transplantation in treating men with previously untreated germ cell tumors.
NCT00002596 ↗ Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed National Cancer Institute (NCI) Phase 3 1994-09-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not known whether combining chemotherapy with bone marrow or peripheral stem cell transplantation is more effective than combination chemotherapy alone in treating men with germ cell tumors. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without bone marrow or peripheral stem cell transplantation in treating men with previously untreated germ cell tumors.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Gonadotropin, Chorionic

Condition Name

Condition Name for Gonadotropin, Chorionic
Intervention Trials
Infertility 72
Polycystic Ovary Syndrome 14
Ovarian Hyperstimulation Syndrome 11
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Condition MeSH

Condition MeSH for Gonadotropin, Chorionic
Intervention Trials
Infertility 95
Polycystic Ovary Syndrome 27
Syndrome 18
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Clinical Trial Locations for Gonadotropin, Chorionic

Trials by Country

Trials by Country for Gonadotropin, Chorionic
Location Trials
United States 317
Egypt 39
Canada 39
China 21
Japan 18
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Trials by US State

Trials by US State for Gonadotropin, Chorionic
Location Trials
California 16
Pennsylvania 13
Illinois 12
New York 11
Minnesota 10
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Clinical Trial Progress for Gonadotropin, Chorionic

Clinical Trial Phase

Clinical Trial Phase for Gonadotropin, Chorionic
Clinical Trial Phase Trials
Phase 4 58
Phase 3 43
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Gonadotropin, Chorionic
Clinical Trial Phase Trials
Completed 106
Unknown status 48
Recruiting 28
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Clinical Trial Sponsors for Gonadotropin, Chorionic

Sponsor Name

Sponsor Name for Gonadotropin, Chorionic
Sponsor Trials
Cairo University 13
Merck KGaA 11
Merck KGaA, Darmstadt, Germany 11
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Sponsor Type

Sponsor Type for Gonadotropin, Chorionic
Sponsor Trials
Other 254
Industry 77
NIH 15
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