Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mayne Glucagon for Injection Compared With Glucagen® (Novo Nordisk) in Healthy Volunteers
Completed
Hospira, Inc.
Phase 1
2007-08-01
The purpose of this study is to evaluate the pharmacokinetics and pharmacodynamic
bioequivalence and safety of Hospira Glucagon for Injection and GlucaGen® in healthy
volunteers.
Pharmacokinetics (PK) and Pharmacodynamics (PD) of Mayne Glucagon for Injection Compared With Glucagen® (Novo Nordisk) in Healthy Volunteers
Completed
Hospira, now a wholly owned subsidiary of Pfizer
Phase 1
2007-08-01
The purpose of this study is to evaluate the pharmacokinetics and pharmacodynamic
bioequivalence and safety of Hospira Glucagon for Injection and GlucaGen® in healthy
volunteers.
The Effect of the GLP-1 Analogue Exenatide on Type 2 Diabetes in CNS and Heart During Hyperglycemia Assessed by PET
Completed
Aarhus University Hospital
Phase 2/Phase 3
2010-02-01
30 type 2 diabetic patients will be PET-scanned twice ( half of the patients heart-PET, half
of the patients CNS-PET) in random order with infusions of placebo or GLP-1-analogue during
hyperglycemic clamp to uncover the metabolic effects of GLP-1-analogues in perspectives of
intervention of macrovascular late diabetic pathology such as stroke and AMI. Earlier studies
have revealed tendencies towards steady glucose metabolism in the CNS despite fluctuations in
blood sugar when infusing native GLP-1.
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