A Study Of PF-04449913 In Japanese Patients With Select Hematologic Malignancies
Active, not recruiting
This is an open-label, multi-center, Phase 1 study of PF-04449913 in Japanese patients.
PF-04449913 will be administered orally as a single agent in patients with select advanced
hematologic malignancies, or in combination with LDAC [Low-Dose Ara-C] or cytarabine and
daunorubicin in previously untreated patients with AML [Acute Myeloid Leukemia] or high-risk
MDS [Myelodysplastic Syndrome], or in combination with azacitidine in previously untreated
patients with AML.
Single-Agent Glasdegib In Patients With Myelofibrosis Previously Treated With Ruxolitinib
A lead-in cohort of ~20 patients with primary or secondary myelofibrosis previously treated
with 1 or more Janus kinase inhibitors enrolled to single-agent glasdegib to evaluate safety
and tolerability. Following the lead-in, a phase 2, double blind, 2-arm study, randomized 2:1
to oral single-agent glasdegib versus placebo in 201 patients resistant or intolerant to
A Combination Study of PF-04449913 (Glasdegib) and Azacitidine In Untreated MDS, AML and CMML Patients
Active, not recruiting
This multi center open label Phase 1b study is designed to evaluate the safety, efficacy,
pharmacokinetics (PK), and pharmacodynamics (PD) of glasdegib (PF-04449913) when combined
with azacitidine in patients with previously untreated Higher Risk Myelodysplastic Syndrome
(MDS), Acute Myeloid Leukemia (AML), or Chronic Myelomonocytic Leukemia (CMML). This clinical
study includes two components: (a) a safety lead in cohort (LIC) and (b) an expansion phase
with an AML cohort and an MDS cohort.
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