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CLINICAL TRIALS PROFILE FOR GLASDEGIB

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All Clinical Trials for Glasdegib

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT02226172	Single-Agent Glasdegib In Patients With Myelofibrosis Previously Treated With Ruxolitinib	Recruiting	Pfizer	Phase 2	2014-10-01	A lead-in cohort of ~20 patients with primary or secondary myelofibrosis previously treated with 1 or more Janus kinase inhibitors enrolled to single-agent glasdegib to evaluate safety and tolerability. Following the lead-in, a phase 2, double blind, 2-arm study, randomized 2:1 to oral single-agent glasdegib versus placebo in 201 patients resistant or intolerant to ruxolitinib.
NCT02367456	A Combination Study of PF-04449913 (Glasdegib) and Azacitidine In 1st Line MDS, AML and CMML Patients	Recruiting	Pfizer	Phase 1	2015-04-01	This multi center randomized (1:1), double blind, placebo controlled Phase 1b/2 study is designed to compare the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of PF 04449913 or placebo when combined with azacitidine in patients with previously untreated Intermediate 2 or High Risk Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML) with 20-30% blasts and multi lineage dysplasia, and Chronic Myelomonocytic Leukemia (CMML). This clinical study includes two components: (a) a Phase 1b safety lead in and (b) a randomized Phase 2.
NCT02430545	Understanding The Effect Of A Strong CYP3A4 Inducer On Glasdegib Pharmacokinetics	Completed	Pfizer	Phase 1	2015-05-01	The study also aims to determine the effect of a strong enzyme (CYP3A4) inducer-rifampin- on drug exposure of Glasdegib. This study will be conducted in healthy subjects given a single dose of glasdegib in each period.

Clinical Trial Conditions for Glasdegib

Condition Name

Condition Name for Glasdegib
Intervention	Trials
Acute Myeloid Leukemia	3
Healthy Volunteers	3
Healthy Volunteer Study	1

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Condition MeSH

Condition MeSH for Glasdegib
Intervention	Trials
Leukemia, Myeloid, Acute	4
Leukemia, Myeloid	4
Leukemia	3

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Clinical Trial Locations for Glasdegib

Trials by Country

Trials by Country for Glasdegib
Location	Trials
United States	33
Japan	13
Spain	4
Belgium	3
Korea, Republic of	3

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Trials by US State

Trials by US State for Glasdegib
Location	Trials
Connecticut	5
Utah	3
New York	3
California	3
Maryland	2

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Clinical Trial Progress for Glasdegib

Clinical Trial Phase

Clinical Trial Phase for Glasdegib
Clinical Trial Phase	Trials
Phase 3	4
Phase 2	2
Phase 1/Phase 2	3

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Clinical Trial Status

Clinical Trial Status for Glasdegib
Clinical Trial Phase	Trials
Not yet recruiting	8
Recruiting	6
Completed	2

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Clinical Trial Sponsors for Glasdegib

Sponsor Name

Sponsor Name for Glasdegib
Sponsor	Trials
Pfizer	10
Plateforme labellisée Inca – Institut Bergonié, Bordeaux	1
Fred Hutchinson Cancer Research Center	1

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Sponsor Type

Sponsor Type for Glasdegib
Sponsor	Trials
Other	13
Industry	10
NIH	1

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