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Last Updated: July 23, 2024

CLINICAL TRIALS PROFILE FOR GLASDEGIB


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All Clinical Trials for Glasdegib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02038777 ↗ A Study Of PF-04449913 In Japanese Patients With Select Hematologic Malignancies Active, not recruiting Pfizer Phase 1 2014-03-25 This is an open-label, multi-center, Phase 1 study of PF-04449913 in Japanese patients. PF-04449913 will be administered orally as a single agent in patients with select advanced hematologic malignancies, or in combination with LDAC [Low-Dose Ara-C] or cytarabine and daunorubicin in previously untreated patients with AML [Acute Myeloid Leukemia] or high-risk MDS [Myelodysplastic Syndrome], or in combination with azacitidine in previously untreated patients with AML.
NCT02226172 ↗ Single-Agent Glasdegib In Patients With Myelofibrosis Previously Treated With Ruxolitinib Terminated Pfizer Phase 2 2014-10-06 A lead-in cohort of ~20 patients with primary or secondary myelofibrosis previously treated with 1 or more Janus kinase inhibitors enrolled to single-agent glasdegib to evaluate safety and tolerability. Following the lead-in, a phase 2, double blind, 2-arm study, randomized 2:1 to oral single-agent glasdegib versus placebo in 201 patients resistant or intolerant to ruxolitinib.
NCT02367456 ↗ A Combination Study of PF-04449913 (Glasdegib) and Azacitidine In Untreated MDS, AML and CMML Patients Active, not recruiting Pfizer Phase 1 2015-04-28 This multi center open label Phase 1b study is designed to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of glasdegib (PF-04449913) when combined with azacitidine in patients with previously untreated Higher Risk Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML), or Chronic Myelomonocytic Leukemia (CMML). This clinical study includes two components: (a) a safety lead in cohort (LIC) and (b) an expansion phase with an AML cohort and an MDS cohort.
NCT02430545 ↗ Understanding The Effect Of A Strong CYP3A4 Inducer On Glasdegib Pharmacokinetics Completed Pfizer Phase 1 2015-05-01 The study also aims to determine the effect of a strong enzyme (CYP3A4) inducer-rifampin- on drug exposure of Glasdegib. This study will be conducted in healthy subjects given a single dose of glasdegib in each period.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Glasdegib

Condition Name

Condition Name for Glasdegib
Intervention Trials
Acute Myeloid Leukemia 6
Healthy Volunteers 3
Myelodysplastic Syndrome 2
Chronic Myelomonocytic Leukemia 2
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Condition MeSH

Condition MeSH for Glasdegib
Intervention Trials
Leukemia, Myeloid 11
Leukemia, Myeloid, Acute 11
Leukemia 10
Preleukemia 4
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Clinical Trial Locations for Glasdegib

Trials by Country

Trials by Country for Glasdegib
Location Trials
United States 44
Japan 22
China 10
Italy 9
Germany 7
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Trials by US State

Trials by US State for Glasdegib
Location Trials
Connecticut 5
California 5
Utah 3
Texas 3
Ohio 3
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Clinical Trial Progress for Glasdegib

Clinical Trial Phase

Clinical Trial Phase for Glasdegib
Clinical Trial Phase Trials
Phase 3 5
Phase 2 4
Phase 1/Phase 2 4
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Clinical Trial Status

Clinical Trial Status for Glasdegib
Clinical Trial Phase Trials
Recruiting 8
Completed 6
Active, not recruiting 5
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Clinical Trial Sponsors for Glasdegib

Sponsor Name

Sponsor Name for Glasdegib
Sponsor Trials
Pfizer 14
National Cancer Institute (NCI) 4
Commissariat A L'energie Atomique 1
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Sponsor Type

Sponsor Type for Glasdegib
Sponsor Trials
Other 20
Industry 15
NIH 4
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