A Study Of PF-04449913 In Japanese Patients With Select Hematologic Malignancies
Active, not recruiting
Pfizer
Phase 1
2014-03-25
This is an open-label, multi-center, Phase 1 study of PF-04449913 in Japanese patients.
PF-04449913 will be administered orally as a single agent in patients with select advanced
hematologic malignancies, or in combination with LDAC [Low-Dose Ara-C] or cytarabine and
daunorubicin in previously untreated patients with AML [Acute Myeloid Leukemia] or high-risk
MDS [Myelodysplastic Syndrome], or in combination with azacitidine in previously untreated
patients with AML.
Single-Agent Glasdegib In Patients With Myelofibrosis Previously Treated With Ruxolitinib
Terminated
Pfizer
Phase 2
2014-10-06
A lead-in cohort of ~20 patients with primary or secondary myelofibrosis previously treated
with 1 or more Janus kinase inhibitors enrolled to single-agent glasdegib to evaluate safety
and tolerability. Following the lead-in, a phase 2, double blind, 2-arm study, randomized 2:1
to oral single-agent glasdegib versus placebo in 201 patients resistant or intolerant to
ruxolitinib.
A Combination Study of PF-04449913 (Glasdegib) and Azacitidine In Untreated MDS, AML and CMML Patients
Active, not recruiting
Pfizer
Phase 1
2015-04-28
This multi center open label Phase 1b study is designed to evaluate the safety, efficacy,
pharmacokinetics (PK), and pharmacodynamics (PD) of glasdegib (PF-04449913) when combined
with azacitidine in patients with previously untreated Higher Risk Myelodysplastic Syndrome
(MDS), Acute Myeloid Leukemia (AML), or Chronic Myelomonocytic Leukemia (CMML). This clinical
study includes two components: (a) a safety lead in cohort (LIC) and (b) an expansion phase
with an AML cohort and an MDS cohort.
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