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McKesson
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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR FLOVENT

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Clinical Trials for Flovent

Trial ID Title Status Sponsor Phase Summary
NCT00071552 Efficacy of QVAR vs Flovent Diskus on Small Airways in Poorly Controlled Asthmatic Adolescents/Adult Patients Terminated Teva Branded Pharmaceutical Products, R&D Inc. Phase 4 The primary objective of this study is to evaluate the effect of Beclomethasone dipropionate HFA on small airways compared to Fluticasone propionate powder for inhalation administered twice daily to poorly controlled asthmatics.
NCT00120978 Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial Unknown status GlaxoSmithKline Phase 4 Large population-based studies suggest that patients with chronic obstructive pulmonary disease (COPD) are 2 to 3 times at risk for cardiovascular mortality, which accounts for a large proportion of the total number of deaths. How COPD increases the risk of poor cardiovascular outcomes is largely unknown. However, there is growing evidence that persistent low-grade systemic inflammation is present in COPD and that this may contribute to the pathogenesis of atherosclerosis and cardiovascular disease among COPD patients. Inflammation and more specifically, C-reactive protein (CRP), has been linked with all stages of atherosclerosis, including plaque genesis, rupture and subsequent thrombo-fibrosis of vulnerable vessels. Recently, our group has demonstrated in a relatively small study that short-term inhaled corticosteroid (ICS) therapy can repress serum CRP levels in stable COPD patients. Conversely, withdrawal of ICS leads to a marked increase in serum CRP levels. Although very promising, these data cannot be considered definitive because the study was small in size and scope (N=41 patients). Additionally, this study did not address the potential effects of combination therapy with ICS and long-acting β2 agonists (LABA). This is an important short-coming because combination therapy of ICS and LABA have been shown to produce improved clinical outcomes over ICS monotherapy and is commonly used by clinicians in the treatment of moderate to severe COPD. We hypothesize that inhaled fluticasone (Flovent®) reduces systemic inflammation and that combination therapy (Advair®) is more effective than steroids alone in reducing systemic inflammation in COPD. In this proposal, we will implement a randomized controlled trial to determine whether ICS by themselves or in combination with LABAs can: 1. reduce CRP levels in stable COPD patients and 2. reduce other pro-inflammatory cytokines, which have been linked with cardiovascular morbidity and mortality such as interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1)
NCT00120978 Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial Unknown status University of British Columbia Phase 4 Large population-based studies suggest that patients with chronic obstructive pulmonary disease (COPD) are 2 to 3 times at risk for cardiovascular mortality, which accounts for a large proportion of the total number of deaths. How COPD increases the risk of poor cardiovascular outcomes is largely unknown. However, there is growing evidence that persistent low-grade systemic inflammation is present in COPD and that this may contribute to the pathogenesis of atherosclerosis and cardiovascular disease among COPD patients. Inflammation and more specifically, C-reactive protein (CRP), has been linked with all stages of atherosclerosis, including plaque genesis, rupture and subsequent thrombo-fibrosis of vulnerable vessels. Recently, our group has demonstrated in a relatively small study that short-term inhaled corticosteroid (ICS) therapy can repress serum CRP levels in stable COPD patients. Conversely, withdrawal of ICS leads to a marked increase in serum CRP levels. Although very promising, these data cannot be considered definitive because the study was small in size and scope (N=41 patients). Additionally, this study did not address the potential effects of combination therapy with ICS and long-acting β2 agonists (LABA). This is an important short-coming because combination therapy of ICS and LABA have been shown to produce improved clinical outcomes over ICS monotherapy and is commonly used by clinicians in the treatment of moderate to severe COPD. We hypothesize that inhaled fluticasone (Flovent®) reduces systemic inflammation and that combination therapy (Advair®) is more effective than steroids alone in reducing systemic inflammation in COPD. In this proposal, we will implement a randomized controlled trial to determine whether ICS by themselves or in combination with LABAs can: 1. reduce CRP levels in stable COPD patients and 2. reduce other pro-inflammatory cytokines, which have been linked with cardiovascular morbidity and mortality such as interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1)
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Flovent

Condition Name

Condition Name for Flovent
Intervention Trials
Asthma 15
Eosinophilic Esophagitis 4
Allergic Asthma 1
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Condition MeSH

Condition MeSH for Flovent
Intervention Trials
Asthma 10
Esophagitis 5
Eosinophilic Esophagitis 5
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Clinical Trial Locations for Flovent

Trials by Country

Trials by Country for Flovent
Location Trials
United States 161
Canada 19
Germany 12
Argentina 10
Brazil 8
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Trials by US State

Trials by US State for Flovent
Location Trials
Florida 9
Wisconsin 8
California 7
Ohio 7
Colorado 7
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Clinical Trial Progress for Flovent

Clinical Trial Phase

Clinical Trial Phase for Flovent
Clinical Trial Phase Trials
Phase 4 11
Phase 3 3
Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Flovent
Clinical Trial Phase Trials
Completed 20
Unknown status 2
Recruiting 2
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Clinical Trial Sponsors for Flovent

Sponsor Name

Sponsor Name for Flovent
Sponsor Trials
GlaxoSmithKline 10
National Heart, Lung, and Blood Institute (NHLBI) 3
Teva Branded Pharmaceutical Products, R&D Inc. 3
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Sponsor Type

Sponsor Type for Flovent
Sponsor Trials
Other 28
Industry 19
NIH 5
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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Fuji
Boehringer Ingelheim
McKesson
Citi
Merck
Farmers Insurance
Baxter
Federal Trade Commission

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