A Long-term Extension Study Evaluating a One-Month Dosing Regimen of Degarelix in Prostate Cancer Requiring Androgen Ablation Therapy
Participants who completed the FE200486 CS21 study (NCT00295750) could enter the FE200486
CS21A study. The study continued until all non-discontinued participants had received
treatment for at least 5 years.
Intermittent Treatment With Degarelix of Patients Suffering From Prostate Cancer
The purpose of this uncontrolled, multi-center, open-label trial was to investigate the
feasibility of using degarelix as intermittent androgen deprivation (IAD) therapy in the
treatment of prostate cancer.
Neoadjuvant Study Investigating Degarelix in Patients Suffering From Prostate Cancer
The purpose of this phase 3B trial was to see how well a new trial drug (degarelix) works in
terms of reducing the size of the prostate volume in prostate cancer patients who were
scheduled to undergo subsequent radiotherapy for treatment of their prostate cancer. Prior to
receiving radiotherapy, it is recommended that patients with intermediate to high risk
prostate cancer are pre-treated with hormone therapy (so-called neoadjuvant therapy) which is
known to reduce the size of the prostate and thereby decrease the required radiation field
and enable a more safe and effective treatment. In this trial, participants were randomly
selected (like flipping a coin) to receive either degarelix given alone or a standard hormone
therapy (combination of goserelin and bicalutamide. The treatment was given for three months
and the prostate size was measured by ultra sound at the beginning and at the end of the
trial. The participants were required to come to the clinic for 5 or 6 visits during the
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