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Generated: December 11, 2018

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CLINICAL TRIALS PROFILE FOR FENTANYL

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Clinical Trials for Fentanyl

Trial ID Title Status Sponsor Phase Summary
NCT00000273 A Laboratory Model for Heroin Abuse Medications - 8 Completed National Institute on Drug Abuse (NIDA) Phase 2 The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."
NCT00000273 A Laboratory Model for Heroin Abuse Medications - 8 Completed New York State Psychiatric Institute Phase 2 The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."
NCT00003000 Morphine for the Treatment of Pain in Patients With Breast Cancer Completed Roswell Park Cancer Institute N/A RATIONALE: Morphine helps to relieve the pain associated with cancer surgery. Giving morphine in different ways may offer more pain relief. PURPOSE: This randomized clinical trial is studying how well morphine injected directly into the underarm area works compared with morphine injected into the back of the shoulder in treating pain in patients who have breast cancer and who are undergoing axillary lymph node dissection.
NCT00004424 Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy Completed Case Western Reserve University N/A OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II. Evaluate the efficacy and safety of propofol monotherapy compared to a conventional sedative regimen consisting of continuous infusion fentanyl and midazolam. III. Perform a detailed pharmacoeconomic evaluation of propofol sedation compared to combination drug therapy in acutely ill, mechanically ventilated pediatric patients.
NCT00004424 Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy Completed FDA Office of Orphan Products Development N/A OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II. Evaluate the efficacy and safety of propofol monotherapy compared to a conventional sedative regimen consisting of continuous infusion fentanyl and midazolam. III. Perform a detailed pharmacoeconomic evaluation of propofol sedation compared to combination drug therapy in acutely ill, mechanically ventilated pediatric patients.
NCT00027014 Herb-Opioid Interactions Completed National Center for Complementary and Integrative Health (NCCIH) Phase 4 This is a series of studies in healthy volunteers to assess the potential for adverse interactions between St. John's wort (SJW) extract and two narcotic (opioid) pain medications: oxycodone and fentanyl. In the case of oxycodone, we are interested in whether SJW treatment promotes the metabolism of oxycodone, such that it lowers the effectiveness of standard doses of oxycodone in treating pain problems. For the fentanyl study, we will investigate whether SJW treatment will interfere with the delivery of fentanyl to the brain and diminish it's effectiveness to relieve pain. There is evidence to suggest that SJW treatment may increase the activity of a transporter protein, named P-glycoprotein (Pgp), in the blood-brain barrier (BBB) that protects the brain from exposure to drugs and other dietary and environmental toxins.
NCT00095251 MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status Active, not recruiting Vanderbilt University Medical Center Phase 2 Delirium has recently been shown as a predictor of death, increased cost, and longer length of stay in ventilated patients. Sedative and analgesic medications relieve anxiety and pain, but may contribute to patients' transitioning into delirium. It is possible that modifying the paradigm for sedation using novel therapies targeted at different receptors, such as dexmedetomidine targeting alpha2 receptors and sparing the GABA receptors, could provide efficacious sedation yet reduce the development, duration, and severity of acute brain dysfunction (delirium).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Fentanyl

Condition Name

Condition Name for Fentanyl
Intervention Trials
Pain 138
Postoperative Pain 54
Pain, Postoperative 52
Cancer 28
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Condition MeSH

Condition MeSH for Fentanyl
Intervention Trials
Pain, Postoperative 136
Breakthrough Pain 37
Chronic Pain 27
Vomiting 26
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Clinical Trial Locations for Fentanyl

Trials by Country

Trials by Country for Fentanyl
Location Trials
United States 721
Canada 76
Egypt 62
Korea, Republic of 57
Turkey 37
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Trials by US State

Trials by US State for Fentanyl
Location Trials
California 57
New York 51
Texas 51
North Carolina 41
Illinois 39
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Clinical Trial Progress for Fentanyl

Clinical Trial Phase

Clinical Trial Phase for Fentanyl
Clinical Trial Phase Trials
Phase 4 343
Phase 3 135
Phase 2/Phase 3 31
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Clinical Trial Status

Clinical Trial Status for Fentanyl
Clinical Trial Phase Trials
Completed 460
Recruiting 193
Not yet recruiting 112
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Clinical Trial Sponsors for Fentanyl

Sponsor Name

Sponsor Name for Fentanyl
Sponsor Trials
Yonsei University 22
Assiut University 22
Mansoura University 18
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Sponsor Type

Sponsor Type for Fentanyl
Sponsor Trials
Other 948
Industry 211
U.S. Fed 15
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