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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR EVOMELA

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Clinical Trials for Evomela

Trial ID Title Status Sponsor Phase Summary
NCT02994784 Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients Not yet recruiting Spectrum Pharmaceuticals, Inc Phase 2 This is a single arm, open label study designed to evaluate the safety and efficacy of propylene glycol-free melphalan hydrochloride in patients with AL amyloidosis. Treatment will be comprised of propylene glycol-free melphalan hydrochloride administered intravenously at a dose of 70-100 mg/m2/day on Days -3 and -2 as conditioning prior to autologous stem cell transplantation.
NCT02994784 Propylene Glycol-Free Melphalan Hydrochloride (Evomela) in AL Amyloidosis Patients Not yet recruiting Shayna Sarosiek Phase 2 This is a single arm, open label study designed to evaluate the safety and efficacy of propylene glycol-free melphalan hydrochloride in patients with AL amyloidosis. Treatment will be comprised of propylene glycol-free melphalan hydrochloride administered intravenously at a dose of 70-100 mg/m2/day on Days -3 and -2 as conditioning prior to autologous stem cell transplantation.
NCT03128359 High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant Recruiting National Cancer Institute (NCI) Phase 2 This pilot phase II trial studies how well high dose cyclophosphamide, tacrolimus, and mycophenolate mofetil work in preventing graft versus host disease in patients with hematological malignancies undergoing myeloablative or reduced intensity donor stem cell transplant. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft versus host disease). Giving high dose cyclophosphamide, tacrolimus, and mycophenolate mofetil after the transplant may stop this from happening.
NCT03128359 High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant Recruiting City of Hope Medical Center Phase 2 This pilot phase II trial studies how well high dose cyclophosphamide, tacrolimus, and mycophenolate mofetil work in preventing graft versus host disease in patients with hematological malignancies undergoing myeloablative or reduced intensity donor stem cell transplant. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft versus host disease). Giving high dose cyclophosphamide, tacrolimus, and mycophenolate mofetil after the transplant may stop this from happening.
NCT03159702 Propylene Glycol-Free Melphalan HCl (EVOMELA®) in Combination With Fludarabine and Total Body Irradiation Based Reduced Intensity Conditioning for Haploidentical Transplantation Not yet recruiting Medical College of Wisconsin Phase 2 This is an open-label, single-arm, phase II study to determine the safety of propylene glycol-free melphalan HCl (EVOMELA®), in combination with fludarabine and total-body irradiation-based reduced-intensity conditioning for haploidentical transplantation. In addition, the study evaluates the one-year progression-free survival of patients undergoing this treatment.
NCT03192397 Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant Recruiting National Cancer Institute (NCI) Phase 2 This phase II trial studies how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant. Drugs used in the chemotherapy, such as fludarabine phosphate and melphalan hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient, they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft versus host disease). Giving cyclophosphamide after the transplant may stop this from happening.
NCT03192397 Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant Recruiting Roswell Park Cancer Institute Phase 2 This phase II trial studies how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant. Drugs used in the chemotherapy, such as fludarabine phosphate and melphalan hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. When the healthy stem cells from a donor are infused into the patient, they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft versus host disease). Giving cyclophosphamide after the transplant may stop this from happening.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Evomela

Condition Name

Condition Name for Evomela
Intervention Trials
Myelodysplastic Syndrome 2
Recurrent Plasma Cell Myeloma 2
Leukemia 2
Multiple Myeloma 2
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Condition MeSH

Condition MeSH for Evomela
Intervention Trials
Multiple Myeloma 5
Neoplasms, Plasma Cell 4
Lymphoma 3
Graft vs Host Disease 2
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Clinical Trial Locations for Evomela

Trials by Country

Trials by Country for Evomela
Location Trials
United States 8
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Trials by US State

Trials by US State for Evomela
Location Trials
Texas 3
Ohio 2
New York 1
California 1
Massachusetts 1
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Clinical Trial Progress for Evomela

Clinical Trial Phase

Clinical Trial Phase for Evomela
Clinical Trial Phase Trials
Phase 2 6
Phase 1/Phase 2 2
Early Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Evomela
Clinical Trial Phase Trials
Not yet recruiting 6
Recruiting 3
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Clinical Trial Sponsors for Evomela

Sponsor Name

Sponsor Name for Evomela
Sponsor Trials
M.D. Anderson Cancer Center 3
National Cancer Institute (NCI) 3
Spectrum Pharmaceuticals, Inc 2
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Sponsor Type

Sponsor Type for Evomela
Sponsor Trials
Other 9
Industry 3
NIH 3
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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Moodys
McKesson
Deloitte
Mallinckrodt
Cantor Fitzgerald
Argus Health
Dow
US Army

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