A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
The purpose of this study is to look at the effects of different methods of birth control
(oral and injectable) on how the body absorbs, makes available, and removes zidovudine
(ZDV). This study will also evaluate the differences in men and women in how the body
absorbs, makes available, and removes ZDV.
Past research has shown that the effectiveness of ZDV as an anti-HIV drug might be decreased
in individuals who use certain methods of birth control. ZDV may also have different effects
in men compared to women.
Medical Treatment of Endometriosis-Associated Pelvic Pain
Completed
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Phase 3
2004-07-01
The Specific Aim of this project is to compare the efficacy and cost-effectiveness of
continuous oral contraceptives versus leuprolide/norethindrone in the treatment of
endometriosis-associated chronic pelvic pain. This comparison will be based on a randomized,
double-blind, trial of women with chronic pelvic pain who have been diagnosed with
endometriosis at the time of surgery within the last 3 years. We hypothesize that, over a
12-month period of postoperative treatment, the efficacy of oral contraceptives is no worse
than leuprolide/norethindrone, and that treatment with oral contraceptives is more
cost-effective.
Study of Bleeding With Extended Administration of an Oral Contraceptive
Completed
Warner Chilcott
Phase 2
2006-06-01
This is an non-comparative study. There is no statistical hypothesis. The effects of
extension of treatment on bleeding will be recorded and described.
Treatment of Non-Gestational Acute Uterine Bleeding: A Randomized Trial
Completed
Kaiser Permanente
N/A
2003-04-01
To determine the relative efficacy of multidose medroxyprogesterone acetate (MPA, Provera)
and a multidose, monophasic combination oral contraceptive in the treatment of
hemodynamically stable women with non-gestational, acute uterine bleeding.
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