A Study to Evaluate the Effects of Different Methods of Birth Control on the Drug Actions of Zidovudine (an Anti-HIV Drug) in HIV-Positive Women and to Compare Zidovudine Metabolism in Men and Women
National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this study is to look at the effects of different methods of birth control
(oral and injectable) on how the body absorbs, makes available, and removes zidovudine (ZDV).
This study will also evaluate the differences in men and women in how the body absorbs, makes
available, and removes ZDV.
Past research has shown that the effectiveness of ZDV as an anti-HIV drug might be decreased
in individuals who use certain methods of birth control. ZDV may also have different effects
in men compared to women.
Medical Treatment of Endometriosis-Associated Pelvic Pain
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
The Specific Aim of this project is to compare the efficacy and cost-effectiveness of
continuous oral contraceptives versus leuprolide/norethindrone in the treatment of
endometriosis-associated chronic pelvic pain. This comparison will be based on a randomized,
double-blind, trial of women with chronic pelvic pain who have been diagnosed with
endometriosis at the time of surgery within the last 3 years. We hypothesize that, over a
12-month period of postoperative treatment, the efficacy of oral contraceptives is no worse
than leuprolide/norethindrone, and that treatment with oral contraceptives is more
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