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Last Updated: August 6, 2020

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CLINICAL TRIALS PROFILE FOR ESTROGENS, CONJUGATED; MEDROXYPROGESTERONE ACETATE

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All Clinical Trials for Estrogens, Conjugated; Medroxyprogesterone Acetate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI) Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 3 1987-09-01 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI) Completed National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 3 1987-09-01 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI) Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 3 1987-09-01 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI) Completed National Institute on Aging (NIA) Phase 3 1987-09-01 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 Postmenopausal Estrogen/Progestin Interventions (PEPI) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1987-09-01 To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00294463 Effects of Tibolone Treatment on the Endometrium Completed Organon Phase 4 2003-02-01 Tibolone, a tissue-selective compound with a combination of estrogenic, progestogenic and androgenic properties, is used as an alternative for estrogen or estrogen plus progesterone hormone therapy for the treatment of symptoms associated with menopause and osteoporosis. The current study compares endometrial histology, biochemistry (hormone levels) and gene-expression profiles after short-term (21-days) treatment with tibolone, to the findings after treatment with estradiol-only (E2) and E2+Medroxyprogesterone Acetate (MPA) in healthy postmenopausal women undergoing hysterectomy for endometrial prolaps. Since short-term tibolone use results in increased spotting and bleeding but long-term treatment with tibolone has been shown to lead to an atrophic endometrium our hypothesis is that tibolone first displays a more estrogenic mode of action, which over time, is counterbalanced by tibolone's progestagenic properties
NCT00294463 Effects of Tibolone Treatment on the Endometrium Completed Erasmus Medical Center Phase 4 2003-02-01 Tibolone, a tissue-selective compound with a combination of estrogenic, progestogenic and androgenic properties, is used as an alternative for estrogen or estrogen plus progesterone hormone therapy for the treatment of symptoms associated with menopause and osteoporosis. The current study compares endometrial histology, biochemistry (hormone levels) and gene-expression profiles after short-term (21-days) treatment with tibolone, to the findings after treatment with estradiol-only (E2) and E2+Medroxyprogesterone Acetate (MPA) in healthy postmenopausal women undergoing hysterectomy for endometrial prolaps. Since short-term tibolone use results in increased spotting and bleeding but long-term treatment with tibolone has been shown to lead to an atrophic endometrium our hypothesis is that tibolone first displays a more estrogenic mode of action, which over time, is counterbalanced by tibolone's progestagenic properties
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Estrogens, Conjugated; Medroxyprogesterone Acetate

Condition Name

Condition Name for Estrogens, Conjugated; Medroxyprogesterone Acetate
Intervention Trials
Osteoporosis 2
Postmenopause 2
Heart Diseases 1
Diabetes Mellitus 1
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Condition MeSH

Condition MeSH for Estrogens, Conjugated; Medroxyprogesterone Acetate
Intervention Trials
Osteoporosis 2
Cardiovascular Diseases 1
Ischemia 1
Lower Urinary Tract Symptoms 1
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Clinical Trial Locations for Estrogens, Conjugated; Medroxyprogesterone Acetate

Trials by Country

Trials by Country for Estrogens, Conjugated; Medroxyprogesterone Acetate
Location Trials
Netherlands 1
Italy 1
Brazil 1
Mexico 1
Taiwan 1
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Clinical Trial Progress for Estrogens, Conjugated; Medroxyprogesterone Acetate

Clinical Trial Phase

Clinical Trial Phase for Estrogens, Conjugated; Medroxyprogesterone Acetate
Clinical Trial Phase Trials
Phase 4 3
Phase 3 2
N/A 1
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Clinical Trial Status

Clinical Trial Status for Estrogens, Conjugated; Medroxyprogesterone Acetate
Clinical Trial Phase Trials
Completed 4
Active, not recruiting 1
Recruiting 1
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Clinical Trial Sponsors for Estrogens, Conjugated; Medroxyprogesterone Acetate

Sponsor Name

Sponsor Name for Estrogens, Conjugated; Medroxyprogesterone Acetate
Sponsor Trials
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 1
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran 1
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1
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Sponsor Type

Sponsor Type for Estrogens, Conjugated; Medroxyprogesterone Acetate
Sponsor Trials
NIH 5
Other 5
Industry 1
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Serving leading biopharmaceutical companies globally:

Colorcon
Express Scripts
Medtronic
Mallinckrodt
Harvard Business School
McKesson

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