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Last Updated: April 13, 2024

CLINICAL TRIALS PROFILE FOR ERDAFITINIB


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All Clinical Trials for Erdafitinib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02365597 ↗ An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer Recruiting Janssen Research & Development, LLC Phase 2 2015-04-22 The purpose of this study is to evaluate the objective response rate (complete response [CR]+ partial response [PR]) of the selected dose regimen in participants with metastatic or surgically unresectable urothelial cancers that harbor specific FGFR genomic alterations.
NCT02421185 ↗ Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 (Erdafitinib) in Participants With Advanced Hepatocellular Carcinoma Completed Janssen Research & Development, LLC Phase 1/Phase 2 2015-05-25 The purpose of this study is to determine recommended Phase 2 dose [RP2D]) and the objective response rate of JNJ-42756493 (erdafitinib) in advanced hepatocellular carcinoma (HCC) participants with fibroblast growth factor (FGF) 19 amplification.
NCT02465060 ↗ Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) Recruiting National Cancer Institute (NCI) Phase 2 2015-08-12 This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
NCT02699606 ↗ A Study to Evaluate the Clinical Efficacy of JNJ-42756493 (Erdafitinib), A Pan-Fibroblast Growth Factor Receptor (FGFR) Tyrosine Kinase Inhibitor, In Asian Participants With Advanced Non-Small-Cell Lung Cancer, Urothelial Cancer, Esophageal Cancer O Active, not recruiting Janssen Research & Development, LLC Phase 2 2016-07-08 The primary purpose of this study is to evaluate objective response rate (ORR) as per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 of erdafitinib in a molecularly-defined subset of Asian participants with non-small-cell lung cancer (NSCLC), urothelial cancer, esophageal cancer and cholangiocarcinoma.
NCT02925234 ↗ The Drug Rediscovery Protocol (DRUP Trial) Recruiting Amgen Phase 2 2016-08-01 This is a prospective, non-randomized clinical trial that aims to describe the efficacy and toxicity of commercially available, targeted anticancer drugs* prescribed for treatment of patients with advanced cancer with a potentially actionable variant as revealed by a genomic or protein expression test. The study also aims to simplify patient access to approved targeted therapies that are contributed to the program by collaborating pharmaceutical companies and to perform next generation sequencing on tumor biopsies for biomarker analyses. Eligible patients have an advanced solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma for which standard treatment options are no longer available and acceptable performance status and organ function. A genomic or protein expression test must have been performed on the tumor and the results must identify at least one potentially actionable molecular variant as defined in the protocol. Results from the molecular profiling test will be used to determine an appropriate drug(s) from among those available in the protocol. The choice of drug will be supported by a list of potential profiles, a molecular tumor board, a knowledge library and by study coordinators for review and approval of the match. The protocol-specified treatment will be administered to the patient once any drug-specific eligibility criteria are confirmed and a fresh pre-treatment biopsy is performed for future genetic studies. All patients who receive treatment with a drug available in the protocol will be followed for standard efficacy outcomes including tumor response, progression-free and overall survival as well as duration of treatment. In addition, treatment related toxicity will be evaluated.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Erdafitinib

Condition Name

Condition Name for Erdafitinib
Intervention Trials
Refractory Malignant Solid Neoplasm 3
Healthy 3
Recurrent Malignant Solid Neoplasm 3
Neoplasm 3
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Condition MeSH

Condition MeSH for Erdafitinib
Intervention Trials
Urinary Bladder Neoplasms 7
Neoplasms 6
Carcinoma 6
Glioma 4
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Clinical Trial Locations for Erdafitinib

Trials by Country

Trials by Country for Erdafitinib
Location Trials
United States 261
Germany 11
Korea, Republic of 8
Taiwan 7
Belgium 7
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Trials by US State

Trials by US State for Erdafitinib
Location Trials
Texas 11
New York 10
Pennsylvania 9
North Carolina 9
Illinois 9
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Clinical Trial Progress for Erdafitinib

Clinical Trial Phase

Clinical Trial Phase for Erdafitinib
Clinical Trial Phase Trials
Phase 3 1
Phase 2 15
Phase 1/Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Erdafitinib
Clinical Trial Phase Trials
Recruiting 13
Not yet recruiting 6
Completed 3
[disabled in preview] 4
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Clinical Trial Sponsors for Erdafitinib

Sponsor Name

Sponsor Name for Erdafitinib
Sponsor Trials
Janssen Research & Development, LLC 12
National Cancer Institute (NCI) 8
Janssen Pharmaceutical K.K. 2
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Sponsor Type

Sponsor Type for Erdafitinib
Sponsor Trials
Industry 31
NIH 8
Other 8
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