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Generated: December 19, 2018

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CLINICAL TRIALS PROFILE FOR EPINEPHRINE; LIDOCAINE HYDROCHLORIDE

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Clinical Trials for Epinephrine; Lidocaine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00001724 Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction Completed National Institute of Dental and Craniofacial Research (NIDCR) Phase 2 This study will evaluate the effectiveness of the non-steroidal anti-inflammatory drug flurbiprofen (Ansaid® (Registered Trademark)) in relieving pain following oral surgery. Flurbiprofen is approved by the Food and Drug Administration for treatment of arthritis pain. Patients 16 years of age and older requiring third molar (wisdom tooth) extraction may be eligible for this study. Patients will undergo oral surgery to remove two lower third molar teeth. Before surgery, they will be given a local anesthetic (lidocaine with epinephrine) injected in the mouth and a sedative (Versed) infused through a catheter (thin plastic tube) placed in an arm vein. At the time of surgery, patients will also be given flurbiprofen or a placebo formulation (look-alike substance with no active ingredient) directly into the extraction site and a capsule that also may contain flurbiprofen or placebo. One in seven patients will receive only placebo. All patients will fill out pain questionnaires and stay in the clinic for up to 6 hours for observation of bleeding and medication side effects. Patients who do not have satisfactory pain relief from the test medicine after surgery may request a standard pain reliever. A small blood sample will be collected during surgery and at 15 minutes, one-half hour and 1, 2, 3, 4, 5, 6, 24 and 48 hours after surgery to measure flurbiprofen blood levels. A total of 33 ml (about 2 tablespoons) of blood will be drawn for these tests. Samples collected on the day of surgery will be drawn from the catheter used to administer the sedative; the 24- and 48-hour samples will be taken by needle from an arm or hand vein. Urine samples will also be collected between 4 and 6 hours after surgery and again at 24 and 48 hours after surgery.
NCT00107822 Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Children Completed ZARS Pharma Inc. Phase 3 The purpose of this study is to evaluate the safety of one treatment of S-Caine™ Peel (skin numbing cream) applied on healthy skin before a painful dermatologic procedure in children. This study will also evaluate how well the S-Caine™ Peel eases the pain of the procedure.
NCT00107835 Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Adults Completed ZARS Pharma Inc. Phase 3 The purpose of this study is to evaluate the safety of one treatment of S-Caine™ Peel (skin numbing cream) applied on healthy skin before a painful dermatologic procedure in adults. This study will also evaluate how well the S-Caine™ Peel eases the pain of the procedure.
NCT00154167 Safety and Efficacy Study of NV-101 in Dental Patients Completed Novalar Pharmaceuticals, Inc. Phase 2 The purpose of this study was: - to determine if NV-101 accelerates recovery from numbness compared to placebo - to evaluate safety of NV-101
NCT00194610 Botox as a Treatment for Interstitial Cystitis in Women Completed Paul G. Allen Family Foundation Phase 4 Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension. Some investigators have even suggested that pelvic floor muscle pain is primarily the cause of bladder problems. Botulinum toxin A causes muscle relaxation by inhibiting the acetylcholine release at the neuromuscular junction. It has been shown that this mechanism relieves pain in a number of muscle spasm-related syndromes. Because, at present, there is little effective therapy available for patients with interstitial cystitis, the researchers want to determine if botulinum toxin A will relieve bladder and pelvic pain in these patients.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Epinephrine; Lidocaine Hydrochloride

Condition Name

Condition Name for Epinephrine; Lidocaine Hydrochloride
Intervention Trials
Pain 19
Anesthesia 8
Postoperative Pain 5
Irreversible Pulpitis 5
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Condition MeSH

Condition MeSH for Epinephrine; Lidocaine Hydrochloride
Intervention Trials
Pain, Postoperative 10
Pulpitis 9
Acute Pain 4
Lacerations 3
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Clinical Trial Locations for Epinephrine; Lidocaine Hydrochloride

Trials by Country

Trials by Country for Epinephrine; Lidocaine Hydrochloride
Location Trials
United States 76
Canada 9
Egypt 5
Iran, Islamic Republic of 5
Germany 4
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Trials by US State

Trials by US State for Epinephrine; Lidocaine Hydrochloride
Location Trials
California 12
New York 6
Maryland 6
Ohio 6
Pennsylvania 5
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Clinical Trial Progress for Epinephrine; Lidocaine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Epinephrine; Lidocaine Hydrochloride
Clinical Trial Phase Trials
Phase 4 46
Phase 3 10
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for Epinephrine; Lidocaine Hydrochloride
Clinical Trial Phase Trials
Completed 61
Recruiting 29
Not yet recruiting 18
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Clinical Trial Sponsors for Epinephrine; Lidocaine Hydrochloride

Sponsor Name

Sponsor Name for Epinephrine; Lidocaine Hydrochloride
Sponsor Trials
University of North Carolina, Chapel Hill 5
Johns Hopkins University 3
Netherlands Institute for Pigment Disorders 3
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Sponsor Type

Sponsor Type for Epinephrine; Lidocaine Hydrochloride
Sponsor Trials
Other 136
Industry 19
U.S. Fed 6
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