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Last Updated: April 22, 2024

CLINICAL TRIALS PROFILE FOR EPHEDRINE HYDROCHLORIDE


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All Clinical Trials for Ephedrine Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00232817 ↗ Anesthesia and Postoperative Pain Completed Columbia University Phase 4 2003-07-01 The purpose of this study is to compare post-operative pain after anesthesia with either isoflurane or propofol. Each group will be further randomized to recieve intranasal nicotine or placebo inorder to detect potetial pronociceptive action of isoflurane. The study is a randomized, prospective, double-blinded controlled trial. Eighty adult women undergoing uterine surgery will be recruited for this study. Enrollment in this study is limited to women, because our animal studies suggest that females have a greater hyperalgesic response to volatile anesthetics than do males. The patient will be given one of two standard anesthetics for their surgery: isoflurane or propofol. We are interested in these two anesthetics because we seek to see if there exists a difference in their effects on a patient's perception of pain, as has been shown to be the case in animal studies but has not yet been studied in humans. The primary outcome variable will be postoperative pain, as measured by a numerical analog pain score (VAS) at 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 120, and 1440 minutes postoperatively. Secondary outcome measures will include morphine utilization via PCA and hemodynamics variables including heart rate, systolic BP, and diastolic BP, all of which will be measured at the same time points as the VAS score.
NCT00267332 ↗ Modafinil in Opioid Induced Sedation Terminated Sidney Kimmel Comprehensive Cancer Center Phase 3 2006-01-01 - The primary objective of this study is to evaluate the efficacy of modafinil in the treatment of opioid induced sedation as measured by the Epworth Sleepiness Scale (ESS). - The secondary objective is to estimate the frequency and severity of toxicity associated with Modafinil (400mg) in patients with opioid induced sedation.
NCT00267332 ↗ Modafinil in Opioid Induced Sedation Terminated Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Phase 3 2006-01-01 - The primary objective of this study is to evaluate the efficacy of modafinil in the treatment of opioid induced sedation as measured by the Epworth Sleepiness Scale (ESS). - The secondary objective is to estimate the frequency and severity of toxicity associated with Modafinil (400mg) in patients with opioid induced sedation.
NCT00377975 ↗ "Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat Completed Pennington Biomedical Research Center Phase 2 2003-01-01 This study compares four treatments to see which one causes the most weight loss, fat loss, loss of abdominal fat and improvement in blood tests like cholesterol. The four treatments are: Placebo, Ephedrine plus caffeine, Pioglitazone, Combined pioglitazone and ephedrine plus caffeine
NCT00426842 ↗ A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride Completed James J. Peters Veterans Affairs Medical Center Phase 2 2007-01-01 With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure. These hemodynamic alterations stimulate the baroreceptor reflex, which is mediated via the central nervous system to increase peripheral sympathetic vasomotor tone, restoring blood pressure and cardiac output within seconds-to-minutes of the assumption of the upright position. Following SCI, individuals often experience the inability to adjust to postural changes due to disruption of central command of the baroreceptor reflex and reduction in efferent sympathetic neural pathways; consequently, orthostatic hypotension (OH) and symptoms of cerebral hypo-perfusion may ensue. OH is a well-documented phenomenon, which is characterized by a fall in systolic blood pressure of >20 mmHg or diastolic BP of > 10 mmHg within 3 minutes of assumption of an upright posture. As a consequence of OH, many individuals experience symptoms of cerebral hypo-perfusion which include lightheadedness, dizziness, blurry vision, fatigue, nausea, ringing in the ears, cognitive impairment and heart palpitations. Although several investigators have reported increased prevalence of OH during the acute phase of spinal cord injury (SCI), individuals with chronic injury also experience significant falls in blood pressure with seated upright postures. This investigation will examine the effects of an alpha-agonist, midodrine hydrochloride, during head-up tilt on systemic blood pressure, cerebral blood flow and cerebral oxygenation compared to placebo administration in persons with chronic SCI who demonstrate significant orthostatic hypotension during a 24-hour observation study. This is the first study to determine the dose response and efficacy of midodrine to improve orthostatic blood pressure and cerebral blood flow and oxygenation in the SCI population.
NCT00432991 ↗ Study of the Effect of Intramuscular Ephedrine on the Incidence of Nausea and Vomiting During Elective Cesarean Section Completed New York Presbyterian Hospital Phase 2 2007-02-01 The purpose of this research study is to investigate if the incidence of nausea and vomiting that subjects experience during and after a Cesarean section can be reduced by giving a shot of the drug ephedrine into the thigh muscle at the time of spinal anesthesia administration.
NCT00432991 ↗ Study of the Effect of Intramuscular Ephedrine on the Incidence of Nausea and Vomiting During Elective Cesarean Section Completed Weill Medical College of Cornell University Phase 2 2007-02-01 The purpose of this research study is to investigate if the incidence of nausea and vomiting that subjects experience during and after a Cesarean section can be reduced by giving a shot of the drug ephedrine into the thigh muscle at the time of spinal anesthesia administration.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Ephedrine Hydrochloride

Condition Name

Condition Name for Ephedrine Hydrochloride
Intervention Trials
Hypotension 23
Anesthesia 18
Postoperative Pain 11
Cesarean Section 11
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Condition MeSH

Condition MeSH for Ephedrine Hydrochloride
Intervention Trials
Hypotension 65
Pain, Postoperative 29
Pre-Eclampsia 11
Vomiting 10
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Clinical Trial Locations for Ephedrine Hydrochloride

Trials by Country

Trials by Country for Ephedrine Hydrochloride
Location Trials
United States 106
Egypt 68
Canada 24
Turkey 20
China 13
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Trials by US State

Trials by US State for Ephedrine Hydrochloride
Location Trials
New York 10
Illinois 7
California 6
Florida 5
Texas 5
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Clinical Trial Progress for Ephedrine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Ephedrine Hydrochloride
Clinical Trial Phase Trials
Phase 4 94
Phase 3 21
Phase 2/Phase 3 12
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Clinical Trial Status

Clinical Trial Status for Ephedrine Hydrochloride
Clinical Trial Phase Trials
Completed 144
Recruiting 42
Not yet recruiting 36
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Clinical Trial Sponsors for Ephedrine Hydrochloride

Sponsor Name

Sponsor Name for Ephedrine Hydrochloride
Sponsor Trials
Ain Shams University 14
Mansoura University 13
Cairo University 12
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Sponsor Type

Sponsor Type for Ephedrine Hydrochloride
Sponsor Trials
Other 276
Industry 13
U.S. Fed 1
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