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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR ENCORAFENIB

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Clinical Trials for Encorafenib

Trial ID Title Status Sponsor Phase Summary
NCT01777776 Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma. Terminated Array BioPharma Phase 1/Phase 2 To evaluate the safety, tolerability and efficacy of LEE011 and LGX818 when administered orally to patients with BRAF mutant melanoma.
NCT01820364 LGX818 in Combination With Agents (MEK162; BKM120; LEE011; BGJ398; INC280) in Advanced BRAF Melanoma Completed Array BioPharma Phase 2 The primary purpose of the Phase II CLGX818X2102 study is to assess the anti-tumor activity of LGX818 in combination with selected agents.
NCT02109653 Efficacy and Safety of LGX818 in Patients With Advanced or Metastatic BRAF V600 Mutant NSCLC Withdrawn Array BioPharma Phase 2 This is an open-label, multi-center, single arm phase II study to evaluate the efficacy and safety of novel BRAF (B-raf murine sarcoma viral oncogene homolog B1) inhibitor encorafenib (LGX818) when used as single agent in patients with advanced or metastatic (stage IIIB or IV) BRAF V600 mutant NSCLC. Patients must have progressed on or after at least one previous systemic, anti-cancer therapy for locally advanced or metastatic NSCLC.
NCT02263898 Intermittent LGX818 and MEK162 in Treating Patients With Metastatic Melanoma Who Have BRAFV600 Mutations Withdrawn National Cancer Institute (NCI) Phase 2 This phase II trial studies intermittent dosing of BRAF inhibitor LGX818 (encorafenib) and MEK inhibitor MEK 162 (binimetinib) in treating patients with melanoma that has spread to other parts of the body (metastatic) and have a BRAF V600 mutation. LGX818 and MEK162 may stop the growth of tumor cells by blocking different enzymes needed for cell growth. Giving LGX818 and MEK162 with breaks between each course (intermittently) may help delay the time when tumors become resistant to the drugs.
NCT02263898 Intermittent LGX818 and MEK162 in Treating Patients With Metastatic Melanoma Who Have BRAFV600 Mutations Withdrawn Jonsson Comprehensive Cancer Center Phase 2 This phase II trial studies intermittent dosing of BRAF inhibitor LGX818 (encorafenib) and MEK inhibitor MEK 162 (binimetinib) in treating patients with melanoma that has spread to other parts of the body (metastatic) and have a BRAF V600 mutation. LGX818 and MEK162 may stop the growth of tumor cells by blocking different enzymes needed for cell growth. Giving LGX818 and MEK162 with breaks between each course (intermittently) may help delay the time when tumors become resistant to the drugs.
NCT02834364 BRAF/MEK Inhibition in Relapsed/Refractory Multiple Myeloma (BIRMA) Recruiting Array BioPharma Phase 2 Trial for patients with refractory multiple myeloma after failure of at least two treatment regimens and with BRAFV600E/K Mutation to evaluate the efficacy of the kinase inhibitors Encorafenib (LGX818 in) combination with Binimetinib (MEK162).
NCT02834364 BRAF/MEK Inhibition in Relapsed/Refractory Multiple Myeloma (BIRMA) Recruiting Coordinating Centre for Clinical Trials Heidelberg Phase 2 Trial for patients with refractory multiple myeloma after failure of at least two treatment regimens and with BRAFV600E/K Mutation to evaluate the efficacy of the kinase inhibitors Encorafenib (LGX818 in) combination with Binimetinib (MEK162).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Encorafenib

Condition Name

Condition Name for Encorafenib
Intervention Trials
Stage IV Melanoma 2
Melanoma 1
Unresectable Stage III Melanoma 1
Malignant Melanoma 1
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Condition MeSH

Condition MeSH for Encorafenib
Intervention Trials
Melanoma 5
Colorectal Neoplasms 1
Neoplasms, Plasma Cell 1
Multiple Myeloma 1
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Clinical Trial Locations for Encorafenib

Trials by Country

Trials by Country for Encorafenib
Location Trials
United States 12
Germany 3
Netherlands 3
Australia 3
Canada 2
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Trials by US State

Trials by US State for Encorafenib
Location Trials
California 2
Tennessee 2
Colorado 2
Washington 1
Connecticut 1
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Clinical Trial Progress for Encorafenib

Clinical Trial Phase

Clinical Trial Phase for Encorafenib
Clinical Trial Phase Trials
Phase 3 1
Phase 2 5
Phase 1/Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Encorafenib
Clinical Trial Phase Trials
Withdrawn 2
Not yet recruiting 2
Recruiting 2
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Clinical Trial Sponsors for Encorafenib

Sponsor Name

Sponsor Name for Encorafenib
Sponsor Trials
Array BioPharma 5
University of Heidelberg Medical Center 1
University Hospital Heidelberg 1
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Sponsor Type

Sponsor Type for Encorafenib
Sponsor Trials
Industry 7
Other 7
NIH 1
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Serving hundreds of leading biopharmaceutical companies globally:

McKinsey
Cipla
Julphar
Express Scripts
Healthtrust
McKesson
Daiichi Sankyo
Argus Health
Fish and Richardson

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