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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR EFFEXOR

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Clinical Trials for Effexor

Trial ID Title Status Sponsor Phase Summary
NCT00001483 Acute Effectiveness of Additional Drugs to the Standard Treatment of Depression Completed National Institute of Mental Health (NIMH) Phase 2 This study will compare the effectiveness of relatively new antidepressants which have different mechanisms of action. Buproprion (Wellbutrin) works on dopamine and the dopaminergic pathway. Sertraline (Zoloft) works as a selective serotonin reuptake inhibitor (SSRI). Venlafaxine (Effexor) works as a mixed serotonin, norepinephrine, and dopamine reuptake inhibitor. Subjects enrolled in this study will be patients diagnosed with a bipolar disorder who are presently taking medication to prevent the symptoms of the disease (prophylactic treatment), but have had breakthrough episodes of depression despite taking their medication. Patients will receive any one of the three antidepressant medications as noted above plus a placebo inactive sugar pill, in order to mask which antidepressant is being prescribed) in addition to their regular medication for bipolar disorder. All of the doses will be calculated as effective for the treatment of a unipolar major depressive disorder. The patient will continue receiving the medication for ten weeks. The effectiveness of the drug treatment will be measured by using three different scales; 1. Inventory for Depressive Symptoms - Clinicians form (IDS-C) 2. Clinical Global Impression scale(CGI-BP) 3. Life Charting Methodology (LCM) Patients who do not respond to their medication within ten weeks from the beginning of the study will be considered as non-responders and be offered the opportunity to start the study again, taking one of the two remaining medications. For example, if a patient was assigned to take Wellbutrin but it was ineffective, he/she could re-enter the study and be given either Zoloft or Effexor. Patients that do respond in the first ten weeks of the study will be eligible to continue taking the medication for one year to assess the long term effectiveness of the drug on preventing episodes of depression and to assess for any possible differential induction of mania.
NCT00043550 Treatments for Depression: Drug Versus Psychotherapy Completed National Institute of Mental Health (NIMH) Phase 3 This 4-8 month study, with a 2-year follow up period, will compare sertraline (Zoloft®), venlafaxine (Effexor®), supportive-expressive psychotherapy, and placebo to determine which is more effective in treating major depression.
NCT00043550 Treatments for Depression: Drug Versus Psychotherapy Completed University of Pennsylvania Phase 3 This 4-8 month study, with a 2-year follow up period, will compare sertraline (Zoloft®), venlafaxine (Effexor®), supportive-expressive psychotherapy, and placebo to determine which is more effective in treating major depression.
NCT00045916 Optimizing Electroconvulsive Therapy for Depression Completed National Institute of Mental Health (NIMH) Phase 4 This study will evaluate the effectiveness of electroconvulsive therapy (ECT) administered with medication for the treatment of a major depressive episode (unipolar or bipolar) and will compare two types of ECT.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Effexor

Condition Name

Condition Name for Effexor
Intervention Trials
Depression 13
Healthy 12
Major Depressive Disorder 9
Depressive Disorder, Major 4
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Condition MeSH

Condition MeSH for Effexor
Intervention Trials
Depression 29
Depressive Disorder 24
Depressive Disorder, Major 14
Disease 10
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Clinical Trial Locations for Effexor

Trials by Country

Trials by Country for Effexor
Location Trials
United States 112
Japan 47
Canada 11
United Kingdom 3
France 3
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Trials by US State

Trials by US State for Effexor
Location Trials
New York 9
Florida 8
North Carolina 6
Missouri 6
Ohio 5
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Clinical Trial Progress for Effexor

Clinical Trial Phase

Clinical Trial Phase for Effexor
Clinical Trial Phase Trials
Phase 4 19
Phase 3 9
Phase 2 5
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Clinical Trial Status

Clinical Trial Status for Effexor
Clinical Trial Phase Trials
Completed 40
Recruiting 6
Withdrawn 4
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Clinical Trial Sponsors for Effexor

Sponsor Name

Sponsor Name for Effexor
Sponsor Trials
Wyeth is now a wholly owned subsidiary of Pfizer 6
Teva Pharmaceuticals USA 5
National Institute of Mental Health (NIMH) 5
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Sponsor Type

Sponsor Type for Effexor
Sponsor Trials
Other 42
Industry 28
NIH 10
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Serving hundreds of leading biopharmaceutical companies globally:

US Department of Justice
McKinsey
Deloitte
Express Scripts
Moodys
Farmers Insurance
Covington
Mallinckrodt
Chubb

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