Evaluation of Substance P Neurotransmission in Panic Disorder by PET Imaging of NK1 Receptors With [18F]SPA-RQ
Completed
National Institute of Mental Health (NIMH)
Phase 1
2004-07-27
This study is designed to observe the effects of a panic attack in patients with panic
disorders and to demonstrate the involvement of Substance P in panic disorder, and thereby,
further our understanding of its role in this illness. We will measure levels of Substance P
in the brain by obtaining pictures of the brain using PET and MRI....
Dosing Chart for Calculating the First Dose of Doxapram in Premature Infants
Completed
Jean Michel Hascoet
Phase 4
2006-11-01
Doxapram is used to stimulate respiration. For a given dose, the fluctuations in
concentrations observed in infants' blood may be wide, leading to a risk of lack of efficacy
or of toxic effects. Two factors are linked to these fluctuations: age and gender. The aim of
this study is to compare a dosage regimen based only on patient's weight, to another one
using a dosing chart taking into account weight, age and gender.
Dosing Chart for Calculating the First Dose of Doxapram in Premature Infants
Completed
Maternite Regionale Universitaire
Phase 4
2006-11-01
Doxapram is used to stimulate respiration. For a given dose, the fluctuations in
concentrations observed in infants' blood may be wide, leading to a risk of lack of efficacy
or of toxic effects. Two factors are linked to these fluctuations: age and gender. The aim of
this study is to compare a dosage regimen based only on patient's weight, to another one
using a dosing chart taking into account weight, age and gender.
We are developing Staccato™ Alprazolam for the treatment of Panic attacks associated with
panic disorder. This study will provide an initial assessment of efficacy, and to continue to
describe the tolerability and pharmacokinetics, of a single inhaled dose of Staccato
Alprazolam on a doxapram-induced panic attack in patients with panic disorder.
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