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Generated: December 18, 2018

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CLINICAL TRIALS PROFILE FOR DOW-ISONIAZID

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Clinical Trials for Dow-isoniazid

Trial ID Title Status Sponsor Phase Summary
NCT00000588 Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 2 To demonstrate the safety and effectiveness of orally-administered pyridoxal isonicotinoyl hydrazone (PIH) for the chronic treatment of iron overload.
NCT00000588 Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone Completed Case Western Reserve University Phase 2 To demonstrate the safety and effectiveness of orally-administered pyridoxal isonicotinoyl hydrazone (PIH) for the chronic treatment of iron overload.
NCT00000636 Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A To evaluate and compare the effectiveness of a 2-month regimen of rifampin and pyrazinamide versus a 1-year course of isoniazid (INH) to prevent the development of tuberculosis in patients who are coinfected with HIV and latent Mycobacterium tuberculosis (MTb). Current guidelines recommend 6 to 12 months of treatment with INH for purified protein derivative (PPD)-positive individuals. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to INH-resistant organisms. Studies suggest that two or three months of rifampin and pyrazinamide may be more effective than longer courses of INH. A two-month prevention course should help to increase compliance. In addition, the use of two drugs (rifampin and pyrazinamide) may help overcome problems with drug resistance.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Dow-isoniazid

Condition Name

Condition Name for Dow-isoniazid
Intervention Trials
Tuberculosis 88
HIV Infections 25
Tuberculosis, Pulmonary 12
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Condition MeSH

Condition MeSH for Dow-isoniazid
Intervention Trials
Tuberculosis 137
Tuberculosis, Pulmonary 35
HIV Infections 31
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Clinical Trial Locations for Dow-isoniazid

Trials by Country

Trials by Country for Dow-isoniazid
Location Trials
United States 267
Canada 44
South Africa 39
Brazil 26
China 18
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Trials by US State

Trials by US State for Dow-isoniazid
Location Trials
California 24
New York 22
Texas 19
Maryland 18
Illinois 18
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Clinical Trial Progress for Dow-isoniazid

Clinical Trial Phase

Clinical Trial Phase for Dow-isoniazid
Clinical Trial Phase Trials
Phase 4 30
Phase 3 41
Phase 2/Phase 3 8
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Clinical Trial Status

Clinical Trial Status for Dow-isoniazid
Clinical Trial Phase Trials
Completed 73
Recruiting 24
Not yet recruiting 22
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Clinical Trial Sponsors for Dow-isoniazid

Sponsor Name

Sponsor Name for Dow-isoniazid
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 27
Centers for Disease Control and Prevention 19
VA Office of Research and Development 10
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Sponsor Type

Sponsor Type for Dow-isoniazid
Sponsor Trials
Other 300
NIH 37
U.S. Fed 33
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Serving hundreds of leading biopharmaceutical companies globally:

Baxter
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Dow
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Colorcon

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