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Last Updated: September 27, 2020

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CLINICAL TRIALS PROFILE FOR DORAVIRINE; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE

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All Clinical Trials for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02397096 Safety and Efficacy of a Switch to MK-1439A in Human Immunodeficiency Virus (HIV-1)-Infected Participants Virologically Suppressed on an Anti-retroviral Regimen in Combination With Two Nucleoside Reverse Transcriptase Inhibitors (MK-1439A-024) Recruiting Merck Sharp & Dohme Corp. Phase 3 2015-06-01 The study will evaluate the safety and efficacy of a switch to MK-1439A (MK-1439 [doravirine] plus lamivudine and tenofovir disoproxil fumarate) in HIV-1-infected participants virologically suppressed on a protocol-specified antiretroviral regimen. The primary hypothesis is that a switch to MK-1439A will be non-inferior to continuation of the regimen at Screening for 24 weeks, as assessed by the proportion of participants maintaining HIV-1 ribonucleic acid (RNA) <50 copies/mL. The Base Study will last up to 50 weeks. An optional Extension Study will evaluate long-term efficacy and safety of the switch to MK-1439A for an additional 2 years.
NCT03332095 Evaluating the Pharmacokinetics, Safety, and Tolerability of Doravirine (MK-1439) and Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (MK-1439A) in HIV-1-Infected Children and Adolescents Not yet recruiting National Institute of Allergy and Infectious Diseases (NIAID) Phase 1/Phase 2 2018-03-01 The purpose of this study is to evaluate the pharmacokinetics, safety, and tolerability of doravirine (also called MK-1439 or DOR) and doravirine/lamivudine/tenofovir disoproxil fumarate (also called MK-1439A or DOR/3TC/TDF) in HIV-1-infected children and adolescents.
NCT04097925 Doravirine Concentrations and Antiviral Activity in Genital Fluids in HIV-1 Infected Individuals Not yet recruiting Hospital Universitari de Bellvitge Phase 2 2019-09-01 This study aims to evaluate the ability of Doravirine to penetrate the genital tract and suppress viral replication and provide evidence for the use of Doravirine as part of treatment strategies as prevention.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate

Condition Name

Condition Name for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Intervention Trials
HIV-1-infection 3
HIV-1 Infection 1
HIV Infections 1
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Condition MeSH

Condition MeSH for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Intervention Trials
HIV Infections 1
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Clinical Trial Locations for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate

Trials by Country

Trials by Country for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Location Trials
United States 16
Spain 3
France 2
South Africa 2
Denmark 1
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Trials by US State

Trials by US State for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Location Trials
Colorado 1
California 1
Arkansas 1
Arizona 1
Texas 1
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Clinical Trial Progress for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate

Clinical Trial Phase

Clinical Trial Phase for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Clinical Trial Phase Trials
Phase 4 1
Phase 3 3
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Clinical Trial Phase Trials
Not yet recruiting 5
Recruiting 1
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Clinical Trial Sponsors for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate

Sponsor Name

Sponsor Name for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Sponsor Trials
Willem Daniel Francois Venter 2
Merck Sharp & Dohme Corp. 1
David Garcia Cinca 1
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Sponsor Type

Sponsor Type for Doravirine; Lamivudine; Tenofovir Disoproxil Fumarate
Sponsor Trials
Other 7
Industry 1
NIH 1
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Serving leading biopharmaceutical companies globally:

Moodys
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Merck
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Colorcon

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