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Last Updated: March 4, 2021

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CLINICAL TRIALS PROFILE FOR DIGOXIN

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All Clinical Trials for Digoxin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000476 Digitalis Investigation Group (DIG) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1990-06-01 To determine if digitalis had a beneficial, harmful, or no effect on total mortality in patients with clinical heart failure and sinus rhythm.
NCT00000547 Enalapril After Anthracycline Cardiotoxicity Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1994-04-01 To determine if the chronic administration of enalapril, an inhibitor of angiotensin converting enzyme (ACE), reduces progression of cardiac dysfunction in pediatric oncology patients who have received anthracyclines, and who are not currently on digoxin, diuretics, or vasodilators for heart failure.
NCT00000556 Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1995-03-01 To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.
NCT00006330 Pharmacokinetic and Pharmacodynamic Interaction Study of Digoxin and Hawthorn Completed National Center for Research Resources (NCRR) N/A 1969-12-31 Hawthorn (Crataegus oxyacantha) is a natural product that is popular in European and American herbal medicine practice. Some of its cardiac uses include the treatment of high and low blood pressure, rapid heart beat, chest pain, and blocked arteries. In many cases, it is used as an adjuvant agent with other cardiac drugs such as digoxin, amiodarone, and warfarin. To date, little information is known about the effect of hawthorn when taken with other drugs and if toxicities occur when hawthorn is used with other drugs. The purpose of this study is to examine the interaction between digoxin and hawthorn in eight healthy subjects. Subjects will be recruited by advertisement. The design of the study will include a 10-day and a three-week treatment phase of digoxin 0.125 mg - 0.25 mg/day and hawthorn (Crataegus special extract WS1442, Schwabe Co.) 450 mg twice daily or placebo, with a randomized crossover. There will be a three-week washout period in between treatment phases. On day 10 (phase I) and day 21 (phase II), subjects will have 12 blood samples drawn for pharmacokinetic analysis. The plasma samples will be measured for digoxin concentration. Additionally, the subjects will be assessed for any clinical toxicities or adverse events. The significance of this study is to provide the clinician with information regarding the safe use of digoxin in combination with the herbal supplement, hawthorn.
NCT00007605 Comparing the Effects of Amiodarone, Sotalol, and Placebo in Maintaining Sinus Rhythm in Patients With Atrial Fibrillation Converted to Sinus Rhythm Completed VA Office of Research and Development Phase 3 1998-04-01 Atrial fibrillation is the most frequently occurring cardiac arrhythmia, with 1.0-1.5 million cases annually. It is a risk factor for congestive heart failure, and stroke, 75,000 cases of the latter occurring annually in patients with atrial fibrillation. The safety of the most widely used antiarrhythmic agent for this group of patients, quinidine, has been called into question. This study seeks to determine whether two other agents, amiodarone and sotalol, are safe and effective treatments for patients with atrial fibrillation.
NCT00027014 Herb-Opioid Interactions Completed National Center for Complementary and Integrative Health (NCCIH) Phase 4 2001-09-01 This is a series of studies in healthy volunteers to assess the potential for adverse interactions between St. John's wort (SJW) extract and two narcotic (opioid) pain medications: oxycodone and fentanyl. In the case of oxycodone, we are interested in whether SJW treatment promotes the metabolism of oxycodone, such that it lowers the effectiveness of standard doses of oxycodone in treating pain problems. For the fentanyl study, we will investigate whether SJW treatment will interfere with the delivery of fentanyl to the brain and diminish it's effectiveness to relieve pain. There is evidence to suggest that SJW treatment may increase the activity of a transporter protein, named P-glycoprotein (Pgp), in the blood-brain barrier (BBB) that protects the brain from exposure to drugs and other dietary and environmental toxins.
NCT00064857 Pycnogenol for the Treatment of Lymphedema of the Arm in Breast Cancer Survivors Completed National Center for Complementary and Integrative Health (NCCIH) Phase 2 2003-08-01 The goal of this study is to evaluate the effectiveness of a standardized botanical extract of Pycnogenol as a treatment for stable arm lymphedema in breast cancer survivors.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Digoxin

Condition Name

Condition Name for Digoxin
Intervention Trials
Healthy 31
Atrial Fibrillation 12
Heart Failure 11
Healthy Volunteers 9
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Condition MeSH

Condition MeSH for Digoxin
Intervention Trials
Heart Failure 21
Atrial Fibrillation 18
Breast Neoplasms 5
Heart Diseases 5
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Clinical Trial Locations for Digoxin

Trials by Country

Trials by Country for Digoxin
Location Trials
United States 137
Germany 18
Canada 15
United Kingdom 10
China 7
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Trials by US State

Trials by US State for Digoxin
Location Trials
Texas 19
Florida 9
California 9
Ohio 8
New York 8
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Clinical Trial Progress for Digoxin

Clinical Trial Phase

Clinical Trial Phase for Digoxin
Clinical Trial Phase Trials
Phase 4 23
Phase 3 15
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for Digoxin
Clinical Trial Phase Trials
Completed 99
Not yet recruiting 29
Recruiting 25
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Clinical Trial Sponsors for Digoxin

Sponsor Name

Sponsor Name for Digoxin
Sponsor Trials
Boehringer Ingelheim 13
Bristol-Myers Squibb 8
AstraZeneca 6
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Sponsor Type

Sponsor Type for Digoxin
Sponsor Trials
Other 133
Industry 106
NIH 12
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