CLINICAL TRIALS PROFILE FOR DIAMOX

All Clinical Trials for Diamox

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00223691 ↗	Treatment of Orthostatic Hypotension in Autonomic Failure	Completed	Vanderbilt University	Phase 1	2002-03-01	The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
NCT00223691 ↗	Treatment of Orthostatic Hypotension in Autonomic Failure	Completed	Vanderbilt University Medical Center	Phase 1	2002-03-01	The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
NCT00262470 ↗	Treatment of Orthostatic Intolerance	Active, not recruiting	National Institutes of Health (NIH)	Phase 1/Phase 2	1997-04-01	This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.
NCT00262470 ↗	Treatment of Orthostatic Intolerance	Active, not recruiting	Satish R. Raj	Phase 1/Phase 2	1997-04-01	This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.
NCT00363571 ↗	The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.	Unknown status	Danish Headache Center	N/A	2006-08-01	After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.
NCT00363792 ↗	Effect of GTN and Diamox Measured by BOLD-Response.	Unknown status	Danish Headache Center	N/A	1969-12-31	In healthy subjects different cerebral haemodynamic values wished to be determined after infusion of the NO donor Glyceryl trinitrate (GTN) and Diamox. The different values we wish to determine are: - Blood-oxygenation-level-Dependent-signal (BOLD-signal) after visual stimulation. - Changes in the diameter of a. cerebri media. - Changes in the regional and global cerebral blodd flow (CBF) with the help of the arterial Spin labeling (ASL) method.
NCT00517426 ↗	Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure	Completed	Centro Cardiologico Monzino	Phase 4	2007-07-01	To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure. Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Clinical Trial Conditions for Diamox

Condition Name

Condition Name for Diamox
Intervention	Trials
Obstructive Sleep Apnea	6
Acute Mountain Sickness	4
Glaucoma	3
Cerebral Edema	2

Condition MeSH

Condition MeSH for Diamox
Intervention	Trials
Altitude Sickness	9
Sleep Apnea Syndromes	7
Sleep Apnea, Obstructive	6
Hypertension	5

Clinical Trial Locations for Diamox

Trials by Country

Trials by Country for Diamox
Location	Trials
United States	52
Belgium	5
Denmark	3
Iran, Islamic Republic of	3
Canada	3

Trials by US State

Trials by US State for Diamox
Location	Trials
California	8
Massachusetts	5
Florida	4
Pennsylvania	3
Minnesota	3

Clinical Trial Progress for Diamox

Clinical Trial Phase

Clinical Trial Phase for Diamox
Clinical Trial Phase	Trials
Phase 4	11
Phase 3	5
Phase 2/Phase 3	2

Clinical Trial Status

Clinical Trial Status for Diamox
Clinical Trial Phase	Trials
Completed	21
Recruiting	10
Unknown status	8

Clinical Trial Sponsors for Diamox

Sponsor Name

Sponsor Name for Diamox
Sponsor	Trials
University of Miami	3
Stanford University	3
Danish Headache Center	3

Sponsor Type

Sponsor Type for Diamox
Sponsor	Trials
Other	72
NIH	6
U.S. Fed	2