"The Effect of Reduced Fluid Load After Cardiac Surgery"
Haukeland University Hospital
The purpose of this study is to verify that an infusion of hypertonic saline/colloids during
cardio-pulmonary-bypass will reduce fluid overload and organ edema for cardiac patients with
Expected beneficial effects are improved organ function for heart and lungs.
The Effect on Fluid Balance After Cardiac Surgery After Use of Two Different Priming Protocols
Haukeland University Hospital
"The impact on fluid loading after cardiac surgery by use of two different priming solution"
Fluid overloading with oedema formation is a regular finding following on-pump cardiac
surgery and may contribute to postoperative organ dysfunction. Myocardial oedema has been
reported to impair both systolic and diastolic function. An association between
intraoperative fluid loading and postoperative adverse outcome has been demonstrated in
The investigators have experience with the use of both colloides and combination fluids
(hypertonic saline/colloides) in several experimental studies (pigs). In one animal study the
investigators used colloides as an additive to the CPB-prime. The investigators observed
reduced fluid leakage and less total tissue water in several organs.
The planned study includes patients scheduled for coronary artery bypass, and who have no
co-morbidity. The patients will be randomized to receive either Tetraspan® (HES) or acetated
Ringer's solution in the CPB-prime. Accurate accounts of fluid additions, blood loss and
diuresis will be kept. Determination of cardiac output (C.O.), intrathoracic blood volume
(ITBV), extravascular lung water (EVLW) and global end diastolic volume (GEDV) will be
monitored by use of the transpulmonary thermodilution technique PiCCO®plus system.
Effects of Desflurane Versus Propofol on Hemostasis During Splenectomy
Theodor Bilharz Research Institute
The aim of this prospective randomized study is to evaluate the perioperative effects of
inhalational anesthesia (desflurane) and intravenous anesthesia (propofol) on hemostasis in
patients undergoing splenectomy with liver cirrhosis guided by the new technology (ROTEM) and
the traditional laboratory hemostatic markers.
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