Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
Completed
National Cancer Institute (NCI)
Phase 3
1996-08-01
Randomized phase III trial to compare the effectiveness of different chemotherapy regimens
with or without bone marrow transplantation in treating children who have acute myelogenous
leukemia or myelodysplastic syndrome. Drugs used in chemotherapy use different ways to stop
cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone
marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and
kill more cancer cells. It is not yet known which treatment regimen is more effective for
acute myelogenous leukemia or myelodysplastic syndrome
Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Completed
National Cancer Institute (NCI)
N/A
2001-04-01
Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop
growing or die. Combining more than one drug may kill more cancer cells. This phase II trial
is studying several different combination chemotherapy regimens to see how well they work in
treating patients with newly diagnosed acute lymphoblastic leukemia
Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia
Completed
National Cancer Institute (NCI)
Phase 3
2002-10-01
This phase II trial is studying how well combination chemotherapy with or without donor
peripheral stem cell transplant works in treating children with acute lymphoblastic leukemia.
Giving combination chemotherapy before a donor peripheral stem cell transplant helps stop the
growth of cancer cells. It also helps stop the patient's immune system from rejecting the
donor's stem cells. When the healthy stem cells from a donor are infused into the patient
they may help the patient's bone marrow make stem cells, red blood cells, white blood cells,
and platelets.
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