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Generated: June 16, 2019

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CLINICAL TRIALS PROFILE FOR DASATINIB

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Clinical Trials for Dasatinib

Trial ID Title Status Sponsor Phase Summary
NCT00036738 Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Da Active, not recruiting National Cancer Institute (NCI) Phase 2 This phase II trial is studying how well fludarabine phosphate and total-body irradiation followed by donor peripheral blood stem cell transplant work in treating patients with acute lymphoblastic leukemia or chronic myelogenous leukemia that has responded to previous treatment with imatinib mesylate, dasatinib, or nilotinib. Giving low doses of chemotherapy, such as fludarabine phosphate, and total-body irradiation (TBI) before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving mycophenolate mofetil and cyclosporine after the transplant may stop this from happening.
NCT00036738 Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Da Active, not recruiting Fred Hutchinson Cancer Research Center Phase 2 This phase II trial is studying how well fludarabine phosphate and total-body irradiation followed by donor peripheral blood stem cell transplant work in treating patients with acute lymphoblastic leukemia or chronic myelogenous leukemia that has responded to previous treatment with imatinib mesylate, dasatinib, or nilotinib. Giving low doses of chemotherapy, such as fludarabine phosphate, and total-body irradiation (TBI) before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving mycophenolate mofetil and cyclosporine after the transplant may stop this from happening.
NCT00070499 Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia Active, not recruiting National Cancer Institute (NCI) Phase 2 This randomized phase IIB trial studies imatinib mesylate at two different doses and dasatinib to see how well they work in treating patients with previously untreated chronic phase chronic myelogenous leukemia. Imatinib mesylate or dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
NCT00101595 Dasatinib (BMS-354825) in Subjects With Lymphoid Blast Phase Chronic Myeloid Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Completed Bristol-Myers Squibb Phase 2 The purpose of this clinical research study is to learn if BMS-354825 will have activity as defined by hematologic responses in subjects with lymphoid blast phase chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia with primary or acquired resistance to imatinib mesylate.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Dasatinib

Condition Name

Condition Name for Dasatinib
Intervention Trials
Chronic Myeloid Leukemia 28
Leukemia 25
Breast Cancer 13
Chronic Myelogenous Leukemia 12
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Condition MeSH

Condition MeSH for Dasatinib
Intervention Trials
Leukemia 140
Leukemia, Myeloid 93
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 91
Leukemia, Lymphoid 57
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Clinical Trial Locations for Dasatinib

Trials by Country

Trials by Country for Dasatinib
Location Trials
Canada 84
United Kingdom 77
Australia 55
France 54
Italy 44
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Trials by US State

Trials by US State for Dasatinib
Location Trials
Texas 78
California 59
New York 48
Florida 47
Illinois 43
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Clinical Trial Progress for Dasatinib

Clinical Trial Phase

Clinical Trial Phase for Dasatinib
Clinical Trial Phase Trials
Phase 4 7
Phase 3 12
Phase 2/Phase 3 4
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Clinical Trial Status

Clinical Trial Status for Dasatinib
Clinical Trial Phase Trials
Completed 90
Recruiting 67
Active, not recruiting 54
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Clinical Trial Sponsors for Dasatinib

Sponsor Name

Sponsor Name for Dasatinib
Sponsor Trials
Bristol-Myers Squibb 109
National Cancer Institute (NCI) 54
M.D. Anderson Cancer Center 33
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Sponsor Type

Sponsor Type for Dasatinib
Sponsor Trials
Other 261
Industry 171
NIH 56
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