ZonMw: The Netherlands Organisation for Health Research and Development
Phase 2
2011-09-01
The aim of the current project is to validate PDE4 inhibitors as a target for cognition
enhancers (proof-of-concept) using a translational behaviour-EEG approach. The project will
demonstrate whether memory, but also attention, information processing or executive function
improves with the PDE4 inhibitor roflumilast in healthy humans.
The aim of the current project is to validate PDE4 inhibitors as a target for cognition
enhancers (proof-of-concept) using a translational behaviour-EEG approach. The project will
demonstrate whether memory, but also attention, information processing or executive function
improves with the PDE4 inhibitor roflumilast in healthy humans.
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
Completed
AstraZeneca
Phase 4
2011-09-30
To demonstrate the additional benefit of roflumilast when added on to fixed-dose combination
(FDC) LABA/ICS in the reduction of exacerbations in subjects with severe to very severe COPD.
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