High Intensity Focused Ultrasound (HIFU) Ablation System Study
The purpose of this study is to determine if the HIFU Pulmonary Vein Ablation System is
effective in the treatment of paroxysmal Atrial Fibrillation compared to the control of best
medical therapy with FDA approved antiarrhythmic drugs.
Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects
Spaulding Clinical Research LLC
This study seeks to compare 4 known QT prolonging drugs versus placebo to determine their
effects on electrophysiological and other clinical parameters. The underlying purpose is to
determine if depolarization and repolarization effects caused by drugs with differing ionic
channel mechanisms can be distinguished from one another, and to gauge the sensitivity and
specificity of novel signal analyses for detection of depolarization and repolarization
changes. Secondarily, to evaluate the exposure response relationship and drug induced
effects on the heart rate biomarker relationship.
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