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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR CYTOMEL


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All Clinical Trials for Cytomel

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00208702 ↗ Thyroid Medication and Antidepressants for Treating Major Depression Completed National Institute of Mental Health (NIMH) Phase 4 1996-09-01 This study will evaluate the effectiveness of treatment with supplemental triiodothyronine (T3, Cytomel) and sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI), in improving symptoms of major depressive disorder (MDD).
NCT00208702 ↗ Thyroid Medication and Antidepressants for Treating Major Depression Completed Emory University Phase 4 1996-09-01 This study will evaluate the effectiveness of treatment with supplemental triiodothyronine (T3, Cytomel) and sertraline (Zoloft), a selective serotonin reuptake inhibitor (SSRI), in improving symptoms of major depressive disorder (MDD).
NCT00265980 ↗ Leptin in Human Energy and Neuroendocrine Homeostasis Terminated Columbia University N/A 2002-07-01 Previous work in our laboratory, and many others, has shown that body weight is regulated. When anyone, fat or thin, tries to maintain a reduced body weight, many systems affecting energy balance (skeletal muscle, neuroendocrine, and autonomic systems) conspire to slow metabolic rate thus favoring the regain of lost weight. Individuals with leptin deficiency are remarkably similar to weight-reduced individuals. Their metabolism, thyroid hormones, and sympathetic nervous system activity are all low despite their obesity. While administration of leptin to leptin-deficient humans results in substantial weight loss and increases in energy expenditure. However, leptin administration to leptin-sufficient humans at usual body weight has little or no effect on weight unless given in doses 10-20 times what would be considered to be in the normal physiological range. This study examines the hypothesis that leptin is "read" by various systems regulating energy balance as an indicator of how much energy we have stored and that the body perceives the weight-reduced state as a condition of relative leptin insufficiency. Within this model, restoration of leptin to levels present prior to weight loss should relieve much of the metabolic opposition to keeping weight off. Preliminary studies support this hypothesis.
NCT00265980 ↗ Leptin in Human Energy and Neuroendocrine Homeostasis Terminated National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) N/A 2002-07-01 Previous work in our laboratory, and many others, has shown that body weight is regulated. When anyone, fat or thin, tries to maintain a reduced body weight, many systems affecting energy balance (skeletal muscle, neuroendocrine, and autonomic systems) conspire to slow metabolic rate thus favoring the regain of lost weight. Individuals with leptin deficiency are remarkably similar to weight-reduced individuals. Their metabolism, thyroid hormones, and sympathetic nervous system activity are all low despite their obesity. While administration of leptin to leptin-deficient humans results in substantial weight loss and increases in energy expenditure. However, leptin administration to leptin-sufficient humans at usual body weight has little or no effect on weight unless given in doses 10-20 times what would be considered to be in the normal physiological range. This study examines the hypothesis that leptin is "read" by various systems regulating energy balance as an indicator of how much energy we have stored and that the body perceives the weight-reduced state as a condition of relative leptin insufficiency. Within this model, restoration of leptin to levels present prior to weight loss should relieve much of the metabolic opposition to keeping weight off. Preliminary studies support this hypothesis.
NCT00265980 ↗ Leptin in Human Energy and Neuroendocrine Homeostasis Terminated Michael Rosenbaum N/A 2002-07-01 Previous work in our laboratory, and many others, has shown that body weight is regulated. When anyone, fat or thin, tries to maintain a reduced body weight, many systems affecting energy balance (skeletal muscle, neuroendocrine, and autonomic systems) conspire to slow metabolic rate thus favoring the regain of lost weight. Individuals with leptin deficiency are remarkably similar to weight-reduced individuals. Their metabolism, thyroid hormones, and sympathetic nervous system activity are all low despite their obesity. While administration of leptin to leptin-deficient humans results in substantial weight loss and increases in energy expenditure. However, leptin administration to leptin-sufficient humans at usual body weight has little or no effect on weight unless given in doses 10-20 times what would be considered to be in the normal physiological range. This study examines the hypothesis that leptin is "read" by various systems regulating energy balance as an indicator of how much energy we have stored and that the body perceives the weight-reduced state as a condition of relative leptin insufficiency. Within this model, restoration of leptin to levels present prior to weight loss should relieve much of the metabolic opposition to keeping weight off. Preliminary studies support this hypothesis.
NCT00296686 ↗ Sequential Tranylcypromine (TC), TC + Dextroamphetamine and TC + Triiodothyronine for Refractory Depression Terminated New York State Psychiatric Institute Phase 4 2001-09-01 This pilot study will assess the efficacy of several sequential pharmacological treatments for patients with Refractory Depression.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Cytomel

Condition Name

Condition Name for Cytomel
Intervention Trials
Hypothyroidism 2
Major Depression 2
Obesity 1
Brain Tumor 1
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Condition MeSH

Condition MeSH for Cytomel
Intervention Trials
Hypothyroidism 3
Depression 3
Thyroid Diseases 2
Sclerosis 2
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Clinical Trial Locations for Cytomel

Trials by Country

Trials by Country for Cytomel
Location Trials
United States 12
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Trials by US State

Trials by US State for Cytomel
Location Trials
Maryland 3
New York 2
Virginia 1
Oregon 1
Pennsylvania 1
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Clinical Trial Progress for Cytomel

Clinical Trial Phase

Clinical Trial Phase for Cytomel
Clinical Trial Phase Trials
Phase 4 2
Phase 2 2
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Cytomel
Clinical Trial Phase Trials
Completed 7
Terminated 4
Recruiting 1
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Clinical Trial Sponsors for Cytomel

Sponsor Name

Sponsor Name for Cytomel
Sponsor Trials
Columbia University 2
Johns Hopkins University 2
Mylan Pharmaceuticals 1
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Sponsor Type

Sponsor Type for Cytomel
Sponsor Trials
Other 12
NIH 4
Industry 1
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