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Generated: March 23, 2019

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CLINICAL TRIALS PROFILE FOR COZAAR

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Clinical Trials for Cozaar

Trial ID Title Status Sponsor Phase Summary
NCT00168857 A Prospective, Randomised, Double-blind, Double-dummy, Forced-titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare Telmisartan (MICARDIS) 80 mg Versus Losartan (COZAAR) 100 mg, in Hypertensive Type 2 Diabetic Patients With Over Completed Boehringer Ingelheim Phase 4 A number of blood pressure lowering drugs in the class known as angiotensin receptor blockers (ARB) have been shown to slow the decline in kidney function of patients with type 2 diabetes, high blood pressure, and kidney disease. Losartan (COZAAR), is one such drug. The purpose of this research study is to determine if after one year of treatment telmisartan (MICARDIS, GLIOSARTAN, KINZAL, KINZALMONO, PREDXAL, PRITOR, SAMERTAN, TELMISARTAN) 80 mg, another blood pressure lowering drug from the ARB class, is as effective as losartan (COZAAR) 100 mg in reducing the level of urinary protein (indicative of improved kidney function).
NCT00223717 Treatment of Supine Hypertension in Autonomic Failure Recruiting Vanderbilt University Medical Center Phase 1/Phase 2 Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension. Drugs used for the treatment of orthostatic hypotension (eg, fludrocortisone and pressor agents), worsen supine hypertension. High blood pressure may also cause target organ damage in this group of patients. The pathophysiologic mechanisms causing supine hypertension in patients with autonomic failure have not been defined. In a study, we, the investigators at Vanderbilt University, examined 64 patients with AF, 29 with pure autonomic failure (PAF) and 35 with multiple system atrophy (MSA). 66% of patients had supine systolic (systolic blood pressure [SBP] > 150 mmHg) or diastolic (diastolic blood pressure [DBP] > 90 mmHg) hypertension (average blood pressure [BP]: 179 ± 5/89 ± 3 mmHg in 21 PAF and 175 ± 5/92 ± 3 mmHg in 21 MSA patients). Plasma norepinephrine (92 ± 15 pg/mL) and plasma renin activity (0.3 ± 0.05 ng/mL per hour) were very low in a subset of patients with AF and supine hypertension. (Shannon et al., 1997). Our group has showed that a residual sympathetic function contributes to supine hypertension in patients with severe autonomic failure and that this effect is more prominent in patients with MSA than in those with PAF (Shannon et al., 2000). MSA patients had a marked depressor response to low infusion rates of trimethaphan, a ganglionic blocker; the response in PAF patients was more variable. At 1 mg/min, trimethaphan decreased supine SBP by 67 +/- 8 and 12 +/- 6 mmHg in MSA and PAF patients, respectively (P < 0.0001). MSA patients with supine hypertension also had greater SBP response to oral yohimbine, a central alpha2 receptor blocker, than PAF patients. Plasma norepinephrine decreased in both groups, but heart rate did not change in either group. This result suggests that residual sympathetic activity drives supine hypertension in MSA; in contrast, supine hypertension in PAF. It is hoped that from this study will emerge a complete picture of the supine hypertension of autonomic failure. Understanding the mechanism of this paradoxical hypertension in the setting of profound loss of sympathetic function will improve our approach to the treatment of hypertension in autonomic failure, and it could also contribute to our understanding of hypertension in general.
NCT00275639 The Effects of Angiotensin II Receptor Blockade on Kidney Function and Scarring After Liver Transplant Completed Mayo Clinic Phase 4 This research study is being done to study the effects, both good and bad, of calcineurin inhibitors and the drug Cozaar (losartan), on kidney function and kidney scarring following a liver transplant.
NCT00340678 Renoprotection in Early Diabetic Nephropathy in Pima Indians Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 3 This investigation is a randomized, double-blinded, placebo-controlled clinical trial in adult diabetic Pima Indians with normal urinary albumin excretion (albumin-to-creatinine ration less than 30 mg/g) or microalbuminuria (albumin-to-creatinine ration = 30-299 mg/g) to test the hypothesis that blockade of the renin-angiotensin system with the angiotensin receptor blocker (ARB) losartan can prevent or further attenuate the development and progression of early diabetic nephropathy in subjects with type 2 diabetes mellitus who are receiving standard diabetes care. One hundred seventy subjects were recruited for the study, all of whom had type 2 diabetes for at least 5 years, serum creatinine concentrations less than 1.4 mg/dl, and no evidence of non-diabetic renal diseases. Ninety-two of the subjects had normal urinary albumin excretion at baseline and other 78 had microalbuminuria. Subjects in each albumin excretion group were randomized to treatment with either the angiotensin II receptor antagonist, losartan, or placebo. Measurements of glomerular filtration rate (GFR), renal plasma flow (RPF) and fractional clearances of albumin and IgG will be made initially, at one month, and at 12-month intervals from baseline thereafter. A kidney biopsy was performed after six years in 111 subjects. Morphometric analysis of renal biopsies was used to determine differences in glomerular structure between treatment groups.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Cozaar

Condition Name

Condition Name for Cozaar
Intervention Trials
Hypertension 20
Healthy 5
Cystic Fibrosis 2
COPD 2
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Condition MeSH

Condition MeSH for Cozaar
Intervention Trials
Hypertension 16
Kidney Diseases 6
Fibrosis 5
Renal Insufficiency, Chronic 3
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Clinical Trial Locations for Cozaar

Trials by Country

Trials by Country for Cozaar
Location Trials
United States 76
China 29
Canada 10
Argentina 4
Korea, Republic of 4
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Trials by US State

Trials by US State for Cozaar
Location Trials
California 7
Florida 7
Massachusetts 6
Georgia 5
New York 4
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Clinical Trial Progress for Cozaar

Clinical Trial Phase

Clinical Trial Phase for Cozaar
Clinical Trial Phase Trials
Phase 4 20
Phase 3 6
Phase 2 7
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Clinical Trial Status

Clinical Trial Status for Cozaar
Clinical Trial Phase Trials
Completed 31
Recruiting 13
Not yet recruiting 5
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Clinical Trial Sponsors for Cozaar

Sponsor Name

Sponsor Name for Cozaar
Sponsor Trials
Merck Sharp & Dohme Corp. 7
University of Miami 3
Boehringer Ingelheim 3
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Sponsor Type

Sponsor Type for Cozaar
Sponsor Trials
Other 48
Industry 30
NIH 8
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