A 12week, Randomized, Evaluator-Masked, Parallel Group Comparing Evening Dosing Of Xalacom Vs Cosopt In Subj W/ Glaucoma
Completed
Pfizer
Phase 4
2005-07-01
To demonstrate the statistical non inferiority of the combination of latanoprost and timolol
given in the evening time once a day vs the combination of dorzamalide and timolol twice a
day based on intraocular pressure measurements at 8 AM, 12 noon & 4 PM during a 12 week
treatment.
A 12week, Randomized, Evaluator-Masked, Parallel Group Comparing Evening Dosing Of Xalacom Vs Cosopt In Subj W/ Glaucoma
Completed
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Phase 4
2005-07-01
To demonstrate the statistical non inferiority of the combination of latanoprost and timolol
given in the evening time once a day vs the combination of dorzamalide and timolol twice a
day based on intraocular pressure measurements at 8 AM, 12 noon & 4 PM during a 12 week
treatment.
To compare the 24-hour efficacy and safety, measured every three hours, of the
dorzolamide/timolol fixed combination given twice daily versus latanoprost and placebo each
given once daily.
To assess the safety and efficacy of a cohort of patients switched to the dorzolamide/timolol
maleate fixed combination because they are insufficiently controlled on latanoprost
monotherapy.
To compare the intraocular pressure effect and safety of the dorzolamide/timolol fixed
combination given twice daily versus bimatoprost given once every evening in patients with
open-angle glaucoma in patients insufficiently controlled on latanoprost monotherapy
To compare the intraocular pressure efficacy and safety of the DTFC given twice daily versus
the LTFC given once every morning following a run-in period with timolol maleate given twice
daily.
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