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Generated: February 20, 2019

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CLINICAL TRIALS PROFILE FOR CONTRAVE

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Clinical Trials for Contrave

Trial ID Title Status Sponsor Phase Summary
NCT00563563 A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent Completed Orexigen Therapeutics, Inc Phase 2 The purpose of this study is to determine whether a combination of naltrexone SR and bupropion SR is safe and effective in the treatment of nicotine-dependence in overweight and obese subjects.
NCT01601704 Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study) Terminated Orexigen Therapeutics, Inc Phase 3 The purpose of this study is to determine the effects of NB relative to placebo on major adverse cardiovascular events (MACE) such as cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke in overweight and obese subjects who are at a higher risk of having these events because they have diabetes and/or other cardiovascular risk factors.
NCT02259179 Bioequivalence Study Comparing Naltrexone SR/Bupropion SR Trilayer Tablets From Two Manufacturers Completed Orexigen Therapeutics, Inc Phase 1 This is a Phase 1, open-label, randomized, single-dose, 2-way crossover study in healthy adult subjects to assess the bioequivalence of naltrexone SR/bupropion SR combination trilayer tablets prepared at two different manufacturing sites. The pharmacokinetics of the two drug products will be evaluated separately in the fed and fasted state.
NCT02638129 Naltrexone/Bupropion Cardiovascular Outcomes Study Terminated Orexigen Therapeutics, Inc Phase 4 The purpose of this study is to evaluate cardiovascular (CV) safety of naltrexone hydrochloride (HCl) and bupropion HCl extended release combination (NB) compared with placebo and rule out excess risk of major adverse cardiovascular events (MACE) when given in combination with standard of care in overweight and obese participants with documented history of CV disease.
NCT03045341 Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment Recruiting National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 2/Phase 3 This study will test the effectiveness and relative efficacy of behavioral and pharmacologic treatments, alone and in combination, for the treatment of binge eating disorder (BED) in patients with obesity. This is an acute treatment comparing behavioral weight loss alone or in combination with naltrexone/bupropion medication.
NCT03045341 Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment Recruiting Yale University Phase 2/Phase 3 This study will test the effectiveness and relative efficacy of behavioral and pharmacologic treatments, alone and in combination, for the treatment of binge eating disorder (BED) in patients with obesity. This is an acute treatment comparing behavioral weight loss alone or in combination with naltrexone/bupropion medication.
NCT03047005 Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy Enrolling by invitation National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 2/Phase 3 This study will test the effectiveness and relative efficacy of naltrexone/bupropion medication as a maintenance therapy for the treatment of binge eating disorder (BED) in patients with obesity. This is a controlled test of whether, amongst responders to acute treatments, naltrexone/bupropion medication results in superior maintenance and longer-term outcomes compared with placebo.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Contrave

Condition Name

Condition Name for Contrave
Intervention Trials
Obesity 8
Binge-Eating Disorder 4
Overweight 2
Bipolar Disorder 1
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Condition MeSH

Condition MeSH for Contrave
Intervention Trials
Binge-Eating Disorder 4
Obesity 4
Feeding and Eating Disorders 4
Bulimia 4
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Clinical Trial Locations for Contrave

Trials by Country

Trials by Country for Contrave
Location Trials
United States 87
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Trials by US State

Trials by US State for Contrave
Location Trials
Connecticut 6
California 3
Ohio 3
Kansas 3
New Jersey 2
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Clinical Trial Progress for Contrave

Clinical Trial Phase

Clinical Trial Phase for Contrave
Clinical Trial Phase Trials
Phase 4 2
Phase 3 1
Phase 2/Phase 3 4
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Clinical Trial Status

Clinical Trial Status for Contrave
Clinical Trial Phase Trials
Recruiting 4
Completed 2
Enrolling by invitation 2
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Clinical Trial Sponsors for Contrave

Sponsor Name

Sponsor Name for Contrave
Sponsor Trials
Yale University 4
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 4
Orexigen Therapeutics, Inc 4
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Sponsor Type

Sponsor Type for Contrave
Sponsor Trials
Other 6
NIH 4
Industry 4
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Serving hundreds of leading biopharmaceutical companies globally:

Cipla
Baxter
Daiichi Sankyo
Merck
Harvard Business School
US Department of Justice
Fuji
Accenture
Deloitte

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