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Generated: December 12, 2018

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CLINICAL TRIALS PROFILE FOR CONIVAPTAN HYDROCHLORIDE

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Clinical Trials for Conivaptan Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00057356 Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure Completed Cumberland Pharmaceuticals Phase 2 This is a randomized, double-blind, placebo-controlled, dose ranging pilot study to examine the effects of conivaptan in patients with acute decompensated heart failure.
NCT00379847 An Open-Label Study of YM087 (Conivaptan) in Patients With Euvolemic or Hypervolemic Hyponatremia Completed Cumberland Pharmaceuticals Phase 3 This study will investigate the application of a vasopressin antagonist in the treatment of hyponatremia most likely caused by inappropriate AVP secretion. The population studied will include patients with euvolemic or hypervolemic hyponatremia.
NCT00435591 A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia Completed Cumberland Pharmaceuticals Phase 4 The study will evaluate the effectiveness and safety of multiple dosing regimens of IV conivaptan in subjects with euvolemic or hypervolemic hyponatremia
NCT00478192 Study of Efficacy & Safety for 3 Infusion Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia Completed Cumberland Pharmaceuticals Phase 3 The study is designed to assess the efficacy and safety of multiple infusions of conivaptan in subjects with euvolemic or hypervolemic hyponatremia
NCT00592475 A Study to Assess the Safety and Effects of Intravenous (IV) Conivaptan on the Hepatic Hemodynamic Response in Cirrhotic Patients Completed Cumberland Pharmaceuticals Phase 2 To evaluate the safety of IV conivaptan in stable euvolemic or hypervolemic cirrhotic patients, and to characterize the effects of IV conivaptan on the hepatic hemodynamic response in patients with cirrhosis.
NCT00684164 Safety and Efficacy of Conivaptan for the Correction of Hyponatremia in Neurological Patients Withdrawn Astellas Pharma Inc Phase 3 Low sodium levels (hyponatremia) are a frequent occurrence in medically ill patients, and in particular those with neurological injury. Hyponatremia has been associated with worse outcome, problems with memory and concentration and impaired balance. Standard treatment for low sodium (salt) levels is to give the patient a salt containing solution thru a catheter (small flexible tube) in a vein in the arm or leg. One of the major complications of this treatment is excess body fluid which may cause heart problems or accumulation of fluid in the lungs and may require additional medications to remove extra water from the body. FDA approval has recently been granted for a new drug - Conivaptan - for use in hyponatremic conditions. Conivaptan works by excreting free water from the body and thereby produce concurrent rise in serum sodium concentrations. Conivaptan has not been evaluated specifically in patients with brain injuries. The primary objective of this study is to demonstrate the safety and efficacy of intravenous Conivaptan for the treatment of hyponatremia in patients with brain injury. If effective, Conivaptan may represent a safe treatment option.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Conivaptan Hydrochloride

Condition Name

Condition Name for Conivaptan Hydrochloride
Intervention Trials
Hyponatremia 9
Heart Failure 3
Cerebral Edema 2
Liver Disease 2
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Condition MeSH

Condition MeSH for Conivaptan Hydrochloride
Intervention Trials
Hyponatremia 9
Heart Failure 6
Liver Diseases 2
Edema 2
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Clinical Trial Locations for Conivaptan Hydrochloride

Trials by Country

Trials by Country for Conivaptan Hydrochloride
Location Trials
United States 49
India 3
Israel 2
Spain 1
Denmark 1
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Trials by US State

Trials by US State for Conivaptan Hydrochloride
Location Trials
New York 4
California 4
Colorado 4
South Carolina 4
Florida 4
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Clinical Trial Progress for Conivaptan Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Conivaptan Hydrochloride
Clinical Trial Phase Trials
Phase 4 4
Phase 3 5
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Conivaptan Hydrochloride
Clinical Trial Phase Trials
Completed 10
Withdrawn 4
Terminated 3
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Clinical Trial Sponsors for Conivaptan Hydrochloride

Sponsor Name

Sponsor Name for Conivaptan Hydrochloride
Sponsor Trials
Cumberland Pharmaceuticals 10
Astellas Pharma Inc 3
Rigshospitalet, Denmark 1
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Sponsor Type

Sponsor Type for Conivaptan Hydrochloride
Sponsor Trials
Industry 14
Other 10
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