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Last Updated: July 1, 2022

CLINICAL TRIALS PROFILE FOR COMTAN


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All Clinical Trials for Comtan

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00262470 ↗ Treatment of Orthostatic Intolerance Active, not recruiting National Institutes of Health (NIH) Phase 1/Phase 2 1997-04-01 This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.
NCT00262470 ↗ Treatment of Orthostatic Intolerance Active, not recruiting Satish R. Raj Phase 1/Phase 2 1997-04-01 This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.
NCT00547911 ↗ Augmenting Effects of L-DOPS With Carbidopa and Entacapone Terminated National Institute of Neurological Disorders and Stroke (NINDS) Phase 1/Phase 2 2007-10-01 An experimental drug called L-DOPS increases production in the body of a messenger chemical called norepinephrine. Cells in the brain that make norepinephrine are often gone in Parkinson disease. The exact consequences of this loss are unknown, but they may be related to symptoms such as fatigue, depression, or decreased attention that occur commonly in Parkinson disease. This study will explore effects of L-DOPS in conjunction with carbidopa and entacapone, which are drugs used to treat Parkinson disease. We wish to find out what the effects are of increasing norepinephrine production in the brain and whether carbidopa and entacapone augment those effects. Volunteers for this study must be at least 18 years of age and able to give consent to participate in the study. To participate in the study, volunteers must discontinue use of alcohol, tobacco, and certain herbal medicines or dietary supplements, and must also taper or discontinue certain kinds of medications that might interfere with the results of the study. Candidates will be screened with a medical history and physical exam. Participants will be admitted to the National Institutes of Health Clinical Center for two weeks of testing. The study will have three testing phases in a randomly chosen order for each participant: - Single dose of L-DOPS - Single dose of L-DOPS in conjunction with carbidopa - Single dose of L-DOPS in conjunction with entacapone Each phase will last two days, with a washout day between each phase in which no drugs will be given and no testing will be performed. In each phase, participants will undergo a series of tests and measurements, including blood pressure and electrocardiogram tests. Participants who are healthy volunteers will also have blood drawn and will undergo a lumbar puncture (also known as a spinal tap) to obtain spinal fluid for chemical tests.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Comtan

Condition Name

Condition Name for Comtan
Intervention Trials
Parkinson Disease 2
Multiple System Atrophy 2
Parkinson's Disease (PD) 1
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Condition MeSH

Condition MeSH for Comtan
Intervention Trials
Parkinson Disease 3
Multiple System Atrophy 2
Atrophy 2
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Clinical Trial Locations for Comtan

Trials by Country

Trials by Country for Comtan
Location Trials
United States 4
China 2
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Trials by US State

Trials by US State for Comtan
Location Trials
Tennessee 2
Oregon 1
Maryland 1
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Clinical Trial Progress for Comtan

Clinical Trial Phase

Clinical Trial Phase for Comtan
Clinical Trial Phase Trials
Phase 2 1
Phase 1/Phase 2 3
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Comtan
Clinical Trial Phase Trials
Unknown status 2
Completed 2
Terminated 1
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Clinical Trial Sponsors for Comtan

Sponsor Name

Sponsor Name for Comtan
Sponsor Trials
National Institutes of Health (NIH) 1
Satish R. Raj 1
National Institute of Neurological Disorders and Stroke (NINDS) 1
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Sponsor Type

Sponsor Type for Comtan
Sponsor Trials
Other 6
NIH 2
U.S. Fed 1
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