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CLINICAL TRIALS PROFILE FOR COL-PROBENECID

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Clinical Trials for Col-probenecid

Trial ID	Title	Status	Sponsor	Phase	Summary
NCT00000670	Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	N/A	To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated quickly from the body, it must be taken frequently. A previous study showed that probenecid slowed the elimination of AZT without side effects, but that study lasted only 5 days. This study is to see whether this effect continues for 1 month and whether the continuation of probenecid and AZT is free of side effects over 1 month.
NCT00000706	Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	N/A	Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and quinine on the same aspects. Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT needed for treatment.
NCT00000799	HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol	Completed	Gilead Sciences	N/A	To evaluate short-term and long-term safety and efficacy of intravenous cidofovir (HPMPC) for treatment of small peripheral cytomegalovirus (CMV) retinitis lesions. To provide data on the relative safety and efficacy of 2 doses of HPMPC as maintenance regimens.

Clinical Trial Conditions for Col-probenecid

Condition Name

Condition Name for Col-probenecid
Intervention	Trials
HIV Infections	10
Cytomegalovirus Retinitis	7
Healthy	5

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Condition MeSH

Condition MeSH for Col-probenecid
Intervention	Trials
HIV Infections	11
Retinitis	7
Cytomegalovirus Retinitis	7

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Clinical Trial Locations for Col-probenecid

Trials by Country

Trials by Country for Col-probenecid
Location	Trials
United States	133
Canada	8
Germany	6
South Africa	6
New Zealand	5

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Trials by US State

Trials by US State for Col-probenecid
Location	Trials
California	11
Texas	9
New York	8
Maryland	8
North Carolina	6

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Clinical Trial Progress for Col-probenecid

Clinical Trial Phase

Clinical Trial Phase for Col-probenecid
Clinical Trial Phase	Trials
Phase 4	5
Phase 3	7
Phase 2/Phase 3	1

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Clinical Trial Status

Clinical Trial Status for Col-probenecid
Clinical Trial Phase	Trials
Completed	31
Not yet recruiting	5
Unknown status	4

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Clinical Trial Sponsors for Col-probenecid

Sponsor Name

Sponsor Name for Col-probenecid
Sponsor	Trials
National Institute of Allergy and Infectious Diseases (NIAID)	8
National Institutes of Health (NIH)	4
Gilead Sciences	3

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Sponsor Type

Sponsor Type for Col-probenecid
Sponsor	Trials
Industry	22
Other	21
NIH	17

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