Study of Clevidipine Assessing Its Postoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-2)
Completed
The Medicines Company
Phase 3
2003-12-01
The purpose of this study is to establish the efficacy of of clevidipine versus placebo in
treating postoperative hypertension. Approximately 100 patients with postoperative
hypertension undergoing coronary artery bypass grafting (CABG), off-pump coronary artery
bypass (OPCAB) or minimally invasive direct coronary artery bypass (MIDCAB) surgery and/or
valve replacement/repair procedures were anticipated to be randomly assigned to one of two
treatment groups: clevidipine or placebo.
Clevidipine in the Perioperative Treatment of Hypertension (ECLIPSE-NTG)
Completed
The Medicines Company
Phase 3
2004-04-01
The purpose of this study is to establish the safety of clevidipine in the treatment of
perioperative hypertension. Approximately 500-900 patients with perioperative hypertension
undergoing coronary artery bypass grafting (CABG), off-pump coronary artery bypass (OPCAB) or
minimally invasive direct coronary artery bypass (MIDCAB) surgery and/or valve
replacement/repair procedures were anticipated to be randomly assigned to one of two
treatment groups: clevidipine or nitroglycerin.
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